Evidence map›Paper›PMID 39733205›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2025

Beneficial Effects of Pomegranate Extracts for Benign Gynecologic Disorders.

Samya El Sayed, Valeria I Macri, Bhuchitra Singh, James H Segars, Md Soriful Islam

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samya El SayedFaculty of Medicine, American University of Beirut, Beirut, Lebanon.
Valeria I MacriDepartment of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Re-search, Johns Hopkins Medicine, Baltimore, MD, 21205, USA.
Bhuchitra SinghDepartment of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Re-search, Johns Hopkins Medicine, Baltimore, MD, 21205, USA.
James H SegarsDepartment of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Re-search, Johns Hopkins Medicine, Baltimore, MD, 21205, USA.
Md Soriful IslamDepartment of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Re-search, Johns Hopkins Medicine, Baltimore, MD, 21205, USA. mislam18@jhmi.edu.ORCID 0000-0001-5595-626X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pomegranate (Punica granatum) is a widely cultivated fruit historically recognized for its health benefits and is regarded as a nutritional powerhouse. Pomegranate has a unique composition of bioactive compounds including hydrolysable tannins, anthocyanins, and other polyphenolic components. Of those, punicalagin and its subsequent metabolites are the most extensively studied, demonstrating antioxidant, anti-inflammatory, anti-cancer, and anti-nociceptive activity. The compounds possess promising therapeutic potential for many diseases, including conditions affecting the female reproductive system. This scoping review examines the pharmacodynamics of pomegranate's bioactive compounds and synthesizes the current literature concerning the role in benign gynecological disorders. Pomegranate extract decreased testosterone levels, levels of oxidative stress and inflammation biomarkers in women with polycystic ovary syndrome, erstwhile favorably impacting some cardiovascular risk factors in women. Pomegranate supplementation improved menopause specific health-related quality of life in women. In a pre-clinical murine model following ovariectomy, improved bone formation and reduced vaginal atrophy were associated with pomegranate treatment. Existing data suggests that additional research on the beneficial antioxidant, anti-inflammatory, anti-proliferative, and anti-nociceptive effects of pomegranate extracts for benign gynecologic conditions is warranted.

Indexed as

Genital Diseases, FemalePlant ExtractsPomegranateAnimalsAntioxidantsFemaleHumansAntioxidantsPlant ExtractsMenopause and osteoporosisOvarian and cervical cancerPolycystic ovary syndromePomegranate

Identifiers

PMID39733205

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.