ArticleScientific reports2024
Harnessing Raman spectroscopy and multimodal imaging of cartilage for osteoarthritis diagnosis.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive Performance of Raman Spectroscopy in Osteoarthritis: A Systematic Review.Journal of medical systems · 2025Pooled it
- Integrated nanoindentation-Raman spectroscopy reveals microscale biomechanical and molecular biomarkers of early intervertebral disc degeneration in a rat model.Materials today. Bio · 2025Article
- Determining mosquito age using surface-enhanced Raman spectroscopy and artificial neural networks: insights into the influence of origin and sex.Parasites & vectors · 2025Article
- Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra.Scientific reports · 2024Article
- Holistic vibrational spectromics assessment of human cartilage for osteoarthritis diagnosis.Biomedical optics express · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Osteoarthritis (OA) is a complex disease of cartilage characterised by joint pain, functional limitation, and reduced quality of life with affected joint movement leading to pain and limited mobility. Current methods to diagnose OA are predominantly limited to X-ray, MRI and invasive joint fluid analysis, all of which lack chemical or molecular specificity and are limited to detection of the disease at later stages. A rapid minimally invasive and non-destructive approach to disease diagnosis is a critical unmet need. Label-free techniques such as Raman Spectroscopy (RS), Coherent anti-Stokes Raman scattering (CARS), Second Harmonic Generation (SHG) and Two Photon Fluorescence (TPF) are increasingly being used to characterise cartilage tissue. However, current studies are based on whole tissue analysis and do not consider the different and structurally distinct layers in cartilage. In this work, we use Raman spectroscopy to obtain signatures from the superficial (top) and deep (bottom) layer of healthy and osteoarthritic cartilage samples from 64 patients (19 control and 45 OA). Spectra were acquired both in the 'fingerprint' region from 700 to 1720 cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.