Evidence map›Paper›PMID 39733518›Full record

ArticleRedox biology2025

ASB1 engages with ELOB to facilitate SQOR ubiquitination and H

Jinxing Lv, Tiantian Wu, Jiajia Xue, Cong Shen, Wenxin Gao, Xia Chen, Yueshuai Guo, Mingxi Liu, Jun Yu, Xiaoyan Huang and 1 more

Abstract read
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. CRL2BMC biology · 2025
    Article
  12. Article
  13. SQOR as a metabolic rheostat of HFrontiers in cell and developmental biology · 2025
    Review
  14. Article
  15. New strategy against sperm oxidative damage: supplementing NaHS to enhance the activity of the HAmerican journal of clinical and experimental immunology · 2025
    Article
  16. Testis-enrichedAmerican journal of translational research · 2025
    Article
  17. Testis-enrichedAmerican journal of translational research · 2025
    Article
  18. Article
  19. Dcun1d3 is dispensable for spermatogenesis and male fertility in mice.American journal of clinical and experimental immunology · 2025
    Article
  20. DCUN1D2 is insignificant for spermatogenesis and male fertility in mice.American journal of translational research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jinxing LvCenter for Reproduction, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, 215124, China. Electronic address: szdalv@163.com.
Tiantian WuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Jiajia XueCenter for Reproduction, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, 215124, China.
Cong ShenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Wenxin GaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Xia ChenInstitute of Reproductive Medicine, Medical School of Nantong University, Nantong University, Nantong, 226001, China.
Yueshuai GuoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Mingxi LiuState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Jun YuInstitute of Reproductive Medicine, Medical School of Nantong University, Nantong University, Nantong, 226001, China. Electronic address: yujun9117@ntu.edu.cn.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China. Electronic address: bbhxy@njmu.edu.cn.
Bo ZhengState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China. Electronic address: bozheng@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility, frequently driven by oxidative stress, impacts half of infertile couples globally. Despite its significance, the precise mechanisms governing this process remain elusive. In this study, we demonstrate that ASB1, the substrate recognition subunit of a ubiquitin ligase, is highly expressed in the mouse testis. Mice lacking the Asb1 gene exhibit severe fertility impairment, characterized by oligoasthenoteratozoospermia. Subsequent investigations unveiled that Asb1 knockout (Asb1-KO) mice encountered excessive oxidative stress and decreased hydrogen sulfide (H

Indexed as

Hydrogen SulfideSpermatogenesisUbiquitinationAnimalsHomeostasisHumansInfertility, MaleMaleMiceMice, KnockoutOxidative StressTestisHydrogen SulfideASB1Hydrogen sulfideOxidative stressPolyubiquitinationSpermiogenesis

Identifiers

PMID39733518
PMCPMC11743861

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.