Trial reportThe Journal of nutrition2025
Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial.
Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830514 (Maximizing the Dietary Pattern of Older Adults), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundReduced meal frequency patterns have become popular for weight loss, maintenance, and improving cardiometabolic health. The extended fasting windows with these dietary patterns could lead to greater protein breakdown, which is a concern for middle-aged and older adults who may need higher protein intakes to maintain or increase net protein balance.
objectivesThis study aimed to quantify muscle and whole-body protein kinetic responses to 3 different daily protein intakes within a 2-meal eating pattern.
methodsThirty participants (age: 61 ± 6 y, BMI: 26.5 ± 4.8 kg/m
resultsWhole-body net protein balance was significantly higher for 1.5 g/kg/d compared with 0.8 g/kg/d [mean difference: 0.55 g/kg; lean body mass (LBM)/d; 95% confidence interval (CI): 0.17, 0.93 g/kg LBM/d; P = 0.004] and 1.1 g/kg/d (mean difference: 0.6 g/kg LBM/d; 95%CI: 0.23, 0.97 g/kg LBM/d; P = 0.001), with no difference between 0.8 and 1.1 g/kg/d (mean difference: 0.05 g/kg LBM/d; 95%CI: -0.31, 0.40 g/kg LBM/d; P = 0.936). Muscle protein synthesis was not significantly different between any groups (P = 0.388).
conclusions: Within a 2-meal eating pattern, a protein intake of 1.5 g/kg/d led to a more positive whole-body net protein balance than intakes of 0.8 and 1.1 g/kg/d in middle-aged and older adults. This trial was registered at clinicaltrials.gov as NCT04830514.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.