ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure-informed normative tractometry.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- [European journal of nuclear medicine and molecular imaging · 2026Article
- SPECTRA: Spatial Inference for Tractometry Toward Precision Mapping of White Matter Microstructure.bioRxiv : the preprint server for biology · 2026Article
- Abnormal signal transmission in white matter revealed by resting-state communication connectivity in Alzheimer's disease: A comprehensive cross-sectional and longitudinal study.Translational psychiatry · 2026Article
- ASSESSING THE INFLUENCE OF TRACTOGRAPHY METHODS ON WHITE MATTER MICROSTRUCTURE AND TRACTOMETRY ANALYSIS IN ALZHEIMERS DISEASE.bioRxiv : the preprint server for biology · 2025Article
- EVALUATING SAMPLE-SIZE EFFICIENCY AND SENSITIVITY OF TRACTOMETRY IN ALZHEIMER'S DISEASE.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal grey matter changes across scales in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Lifespan Normative Modeling of Brain Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Streamline Density Normalization: A Robust Approach to Mitigate Bundle Variability in Multi-Site Diffusion MRI.bioRxiv : the preprint server for biology · 2025Article
- Synthetic Diffusion Tensor Imaging Maps Generated by 2D and 3D Probabilistic Diffusion Models: Evaluation and Applications.bioRxiv : the preprint server for biology · 2025Article
- Recent Insights into the Neurobiology of Alzheimer's Disease and Advanced Treatment Strategies.Molecular neurobiology · 2025Review
- Accuracy and clinical applicability of plasma tau 181 and 217 for Alzheimer's disease diagnosis in a memory clinic cohort.Journal of neurology · 2025Article
- Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure-informed normative tractometry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Amyloid, Tau, and APOE in Alzheimer's Disease: Impact on White Matter Tracts.bioRxiv : the preprint server for biology · 2024Article
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17 authors.
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Abstract
introductionDiffusion-weighted magnetic resonance imaging (dMRI) is sensitive to the microstructural properties of brain tissues and shows great promise in detecting the effects of degenerative diseases. However, many approaches analyze single measures averaged over regions of interest without considering the underlying fiber geometry.
methodsWe propose a novel macrostructure-informed normative tractometry (MINT) framework to investigate how white matter (WM) microstructure and macrostructure are jointly altered in mild cognitive impairment (MCI) and dementia. We compared MINT-derived metrics with univariate diffusion tensor imaging (DTI) metrics to examine how fiber geometry may impact the interpretation of microstructure.
resultsIn two multisite cohorts from North America and India, we find consistent patterns of microstructural and macrostructural anomalies implicated in MCI and dementia; we also rank diffusion metrics' sensitivity to dementia. DISCUSSION: We show that MINT, by jointly modeling tract shape and microstructure, has the potential to disentangle and better interpret the effects of degenerative disease on the brain's neural pathways. HIGHLIGHTS: Changes in diffusion tensor imaging metrics may be due to macroscopic changes. Normative models encode normal variability of diffusion metrics in healthy controls. Variational autoencoder applied on tractography can learn patterns of fiber geometry. WM microstructure and macrostructure are modeled with multivariate methods. Transfer learning uses pretraining and fine-tuning for increased efficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.