Evidence map›Paper›PMID 39737778›Full record

ArticleMagnetic resonance in medicine2025

WALINET: A water and lipid identification convolutional neural network for nuisance signal removal in

Paul J Weiser, Georg Langs, Stanislav Motyka, Wolfgang Bogner, Sébastien Courvoisier, Malte Hoffmann, Antoine Klauser, Ovidiu C Andronesi

Abstract readComparative Study
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul J WeiserAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0004-2503-5696
Georg LangsComputational Imaging Research Lab-Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Stanislav MotykaHigh Field MR Center-Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-6314-316X
Wolfgang BognerHigh Field MR Center-Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Sébastien CourvoisierCenter for Biomedical Imaging (CIBM), Geneva, Switzerland.ORCID https://orcid.org/0000-0001-9309-4154
Malte HoffmannAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.
Antoine KlauserAdvanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-3019-9914
Ovidiu C AndronesiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7412-0641

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Benjamin Harris Kann · 2013 to 2026
$33.5M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Development of whole-brain in vivo 2HG imaging for precision medicine in mutant IDH gliomaR01CA211080 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Ovidiu C Andronesi · 2017 to 2026
$5.4M
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patientsR01CA255479 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDRONESI, OVIDIU C · 2021 to 2025
$3.0M
Fast motion-robust fetal neuroimaging with MRIR00HD101553 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, MALTE · 2023 to 2025
$743k
Austrian Science Fund WEAVE I 6037 & P34198National Institute of Health 2R01CA211080-06A1National Institute of Health P41EB015896National Institute of Health P50CA165962National Institute of Health R01CA255479NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA211080NCI NIH HHS R01 CA255479NIBIB NIH HHS P41 EB015896NICHD NIH HHS R00 HD101553The Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK)
6 · The paper itself

Abstract

purposeProton magnetic resonance spectroscopic imaging (

methodsWe introduce a deep learning method based on a modified Y-NET network for water and lipid removal in whole-brain

resultsWALINET is significantly faster and needs 8s for high-resolution whole-brain MRSI, compared with 42min for conventional HLSVD+L2. WALINET suppresses lipid and water in the brain by 25-45 and 34-53-fold, respectively. WALINET has better performance than HLSVD+L2, providing: (1) more lipid removal with 41% lower NRMSE; (2) better metabolite signal preservation with 71% lower NRMSE in simulated data; 155% higher SNR and 50% lower CRLB in in vivo data. Metabolic maps obtained by WALINET in healthy subjects and patients show better gray-/white-matter contrast with more visible structural details.

conclusionsWALINET has superior performance for nuisance signal removal and metabolite quantification on whole-brain

Indexed as

BrainConvolutional Neural NetworksImage Processing, Computer-AssistedLipidsNeural Networks, ComputerProton Magnetic Resonance SpectroscopyWaterAdultAlgorithmsDeep LearningFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleLipidsWaterbrainmetabolite quantificationmr spectroscopic imagingultrahigh‐field mrwater and lipid removal

Identifiers

PMID39737778
PMCPMC11782715

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.