Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Rachel Baum *Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0002-8227-7462
Vu D Nguyen *Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0009-0007-6250-8271
Mario MaaloufNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0003-2998-5395
Daisuke ShimuraNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0002-9954-2162
Miriam WaghalterNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0009-0000-4549-8293
Sargis SrapyanDepartment of Chemistry and Biochemistry, California State University, Long Beach (CSULB), Long Beach, CA, USA.ORCID 0009-0001-0117-1624
Qianru JinDisease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University , Boston, MA, USA.ORCID 0000-0003-3182-8188
Lucas KuzmanovichNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0009-0008-7913-2319
Adelaide T GaffneyNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0009-0000-8249-6051
Bridger R BellNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0009-0007-0424-0617
Shaohua XiaoDepartment of Neurology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0009-0003-5125-6284
Joseph A PalatinusNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0002-6424-0105
André G KléberDisease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University , Boston, MA, USA.ORCID 0000-0002-3233-2005
Elena E GrintsevichDepartment of Chemistry and Biochemistry, California State University, Long Beach (CSULB), Long Beach, CA, USA.ORCID 0000-0002-9671-6139
TingTing HongNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0002-0243-5046
Robin M ShawNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah , Salt Lake City, UT, USA.ORCID 0000-0001-7429-6092
Funding
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Regulation of Cav1.2 Trafficking by GJA1-20k and cBIN1R01HL159983 · NHLBI · UNIVERSITY OF UTAH · PI HONG, TINGTING, SHAW, ROBIN M · 2021 to 2024
$2.2M
Regulation of Ion Channels at BIN1-induced T-tubule MicrodomainsR01HL133286 · NHLBI · UNIVERSITY OF UTAH · PI HONG, TINGTING · 2016 to 2020
$2.2M
A New Non-Canonical Role for an Alternatively Translated Ion Channel ProteinR01HL138577 · NHLBI · UNIVERSITY OF UTAH · PI SHAW, ROBIN M · 2017 to 2020
$2.1M
Unlocking Trafficking Specificity for Cx43 Gap JunctionsR01HL152691 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Robin M Shaw · 2020 to 2026
$2.0M
Altered Cell-Cell Coupling in Arrhythmogenic CardiomyopathyR01HL136463 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAFFITZ, JEFFREY E · 2018 to 2021
$1.8M
GJA1-20K is a new regulator of actin dynamics and myocardial cell-cell couplingF31HL147404 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAUM, RACHEL · 2019 to 2021
While membrane proteins such as ion channels continuously turn over and require replacement, the mechanisms of specificity of efficient channel delivery to appropriate membrane subdomains remain poorly understood. GJA1-20k is a truncated Connexin43 (Cx43) isoform arising from translation initiating at an internal start codon within the same parent GJA1 mRNA and is requisite for full-length Cx43 trafficking to cell borders. GJA1-20k does not have a full transmembrane domain, and it is not known how GJA1-20k enables forward delivery of Cx43 hemichannels. Here, we report that a RPEL-like domain at the C terminus of GJA1-20k binds directly to actin and induces an actin phenotype similar to that of an actin-capping protein. Furthermore, GJA1-20k organizes actin within the cytoplasm to physically outline a forward delivery pathway for microtubule-based trafficking of Cx43 channels to follow. In conclusion, we find that the postal address of membrane-bound Cx43 channel delivery is defined by a separate protein encoded by the same mRNA of the channel itself.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. · full record | Socratic