Evidence map›Paper›PMID 39737893›Full record

ArticleNutrition & diabetes2024

The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.

Peng Zhang, Wanbo Zhu, Yongkang Wang, Nikolaos Kourkoumelis, Chen Zhu, Xianzuo Zhang, Weiwei Zhang

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In one paragraph

Article in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng Zhang *Department of Orthopedics, The Affiliated Provincial Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Wanbo Zhu *Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yongkang WangDepartment of International Medical, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Nikolaos KourkoumelisDepartment of Medical Physics, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Chen ZhuDepartment of Orthopedics, The Affiliated Provincial Hospital of Anhui Medical University, Anhui Medical University, Hefei, China. zhuchena@ustc.edu.cn.ORCID 0000-0002-7774-2219
Xianzuo ZhangDepartment of Orthopedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China. zhangxianzuo@foxmail.com.ORCID 0000-0002-6432-7745
Weiwei ZhangDepartment of International Medical, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China. zhangxueweiwei@sina.com.ORCID 0000-0002-6813-6815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes mellitus (DM) and arthritis are prevalent conditions worldwide. The intricate relationship between these two conditions, especially in the context of various subtypes of arthritis, remains a topic of interest.

objectiveTo investigate the relationship between diabetes and arthritis, with a focus on Rheumatoid Arthritis (RA), using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis.

methodsData from six consecutive NHANES cycles from 2007 to 2018 were analyzed, involving 30,062 participants after applying exclusion criteria. The association between diabetes and arthritis was assessed using logistic regression. MR was employed to determine the causal relationship between the two conditions using Genome-Wide Association Study (GWAS) data.

resultsThe prevalence of arthritis in diabetic patients was almost twice that of non-diabetic patients. Logistic regression showed a significant gross association between arthritis and diabetes with an OR of 2.90 (95% CI: 2.66-3.16). After adjusting for age, gender, race, and other factors, the association yielded an OR of 1.14 (95% CI: 1.00-1.29, p < 0.05). MR analyses indicated a significant association between Type 1 Diabetes and RA (OR = 1.407, p = 0.002), but no significant correlation was observed for Type 2 Diabetes.

conclusionThere is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.

Indexed as

Arthritis, RheumatoidGenome-Wide Association StudyMendelian Randomization AnalysisNutrition SurveysAdultAgedArthritisDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseHumansLogistic ModelsMaleMiddle AgedPolymorphism, Single Nucleotide

Identifiers

PMID39737893
PMCPMC11683145

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.