ArticleNature communications2024
Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07236515 (Randomized, Sham-Controlled, Multicenter Investigation of the Leia Sensory Prosthesis on Gait and Balance in Peripheral Neuropathy.), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Sham-Controlled, Multicenter Investigation of the Leia Sensory Prosthesis on Gait and Balance in Peripheral Neuropathy.
Who cites it
12 citing papers in PubMed.
- Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial.Nature medicine · 2026Trial
- Comfort, consistency, and efficiency of garments with textile electrodes versus hydrogel electrodes for neuromuscular electrical stimulation in a randomized crossover trial.Scientific reports · 2025Trial
- Bending-Resistant Intimate 3D Graphene-Metal Heterojunctions for Highly Sensitive and Robust Flexible Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions.Bioactive materials · 2026Review
- Merging neural stimulation and exoskeletons to enhance sensorimotor hand functions after brain or spinal cord injury.Science advances · 2026Article
- Sensory and cortical biomarkers unveil pain modulation mechanisms induced by targeted multisensory neurostimulation.Journal of neuroengineering and rehabilitation · 2026Article
- A Fully Self-Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanomedicine.Nature reviews bioengineering · 2026Article
- Thermo-Responsive Self-Recoverable Porous Sensors with Writable Electrodes: Advancing Wearable Motion Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Diabetic Peripheral Neuropathy: New Diagnostics and Treatment Perspectives.Drugs & aging · 2026Review
- Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles.Bioactive materials · 2025Article
- Wearable devices in neurological disorders: a narrative review of status quo and perspectives.Annals of translational medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain and increased fall risk. However, present treatments do not counteract sensory loss, but only partially manage its consequences. Electrical neural stimulation holds promise to restore sensations, but its efficacy and benefits in PN damaged nerves are yet unknown. We designed a wearable sensory neuroprosthesis (NeuroStep) providing targeted neurostimulation of the undamaged nerve portion and assessed its functionality in 14 PN participants. Our system partially restored lost sensations in all participants through a purposely calibrated neurostimulation, despite PN nerves being less sensitive than healthy nerves (N = 22). Participants improved cadence and functional gait and reported a decrease of neuropathic pain after one day. Restored sensations activated cortical patterns resembling naturally located foot sensations. NeuroStep restores real-time intuitive sensations in PN participants, holding potential to enhance functional and health outcomes while advancing effective non-invasive neuromodulation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.