Evidence map›Paper›PMID 39738281›Full record

ArticleScientific reports2024

Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach.

Muhammad Ramzan, Sajid Mahmood, Adnan Amjad, Mohsin Javed, Ammar Zidan, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Namrah Zaka, Shazia Khurshid and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muhammad Ramzan *Department of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Sajid Mahmood *Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.
Adnan AmjadDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan. adnan.amjad@umt.edu.pk.
Mohsin JavedDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Ammar ZidanBiomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babylon, 51001, Iraq.
Ali BahadurDepartment of Chemistry, College of Science, Mathematics, and Technology, Wenzhou-Kean University, Wenzhou, 325060, Zhejiang Province, China. abahadur@wku.edu.cn.
Shahid IqbalNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. Shahid.Iqbal@nottingham.edu.cn.
Muhammad SaadCentre for Organic and Nanohybrid Electronics, Silesian University of Technology, Konarskiego 22B, Gliwice, 44-100, Poland. saad.miana786@gmail.com.
Namrah ZakaDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Shazia KhurshidDepartment of Chemistry, Government College University Lahore, Lahore, 54000, Pakistan.
Nasser S AwwadChemistry Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia.
Hala A IbrahiumBiology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia.
Toheed AkhterDepartment of Chemical and Biological Engineering, Gachon University, Seongnam, 13120, Republic of Korea.

Funding

King Khalid University RGP2/148/45
6 · The paper itself

Abstract

The Crimean Congo virus has been reported to be a part of the spherical RNA-enveloped viruses from the Bunyaviridae family. Crimean Congo fever (CCHF) is a fatal disease with having fatality rate of up to 40%. It is declared endemic by the World Health Organization. Many outbreaks of CCHF have been reported over the years. Former studies on CCHF have reported that the nucleoprotein of CCHF, being a pivotal protein in the replication process of the virus, is a potential target for antiviral drugs. However, there is no specific drug that can be used to treat this fatal disease and laboratory testing is prohibited due to its pathogen level 4. This study aims to find a possible potential inhibitor of the nucleoprotein of CCHFV using modern techniques leading ultimately to the development of effective and natural drugs. In this study, a virtual screening procedure involving a docking process followed by the Molecular Dynamics method is used to find out the potential inhibitors of the nucleoprotein of CCHFV. Phytochemicals having pharmacological properties and approved by the Food and Drug Administration are docked over the nucleoprotein of CCHFV. The study signifies the use of Withanolide E as a drug for the treatment of CCHFV as the study depicts the potential of Withanolide E to inhibit the nucleoprotein of CCHFV using reliable and modern techniques.

Indexed as

Antiviral AgentsHemorrhagic Fever Virus, Crimean-CongoMolecular Docking SimulationNucleoproteinsPhytochemicalsComputer SimulationHumansMolecular Dynamics SimulationAntiviral AgentsNucleoproteinsPhytochemicalsBunyaviralCrimean CongoDockingNucleoprotein of CCHFVirtual screening procedure

Identifiers

PMID39738281
PMCPMC11685418

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.