ArticleScientific reports2024
SS-OCTA assessment of fundus microvascular changes and their correlation with coronary lesion severity in severe coronary heart disease.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Association of the apolipoproteins with retinal arteriosclerosis in a health examination population.Frontiers in cardiovascular medicine · 2026Article
- A lightweight DeepME model based on improved YOLOv11 architecture for macular edema detection and treatment monitoring.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
This study aimed to quantify fundus microvascular alterations in patients requiring revascularization for coronary heart disease (CHD) using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate the correlation between these alterations and the severity of coronary artery lesions. SS-OCTA was employed to assess the fundus neurovascular parameters of all participants, while the Gensini score was utilized to gauge the severity of coronary artery lesions in observation group. A total of 98 participants (49 CHD patients and 49 controls) were included. Analysis of the SS-OCTA parameters revealed that the vascular density (VD) of the superficial vascular plexus (SVP), the superficial vascular complex (SVC), the intermediate capillary plexus (ICP) in the parafoveal region, the mean ICP in the macula, deep capillary plexus (DCP) and deep vascular complex (DVC) in each macular region were significantly reduced in the observation group compared to the control group (P < 0.05). Multivariate logistic regression indicated that lower VD values in the SVP, SVC, ICP, DCP and DVC across macular regions were significantly associated with an increased likelihood of severe CHD (OR < 1, P < 0.05). ROC curve analysis revealed that the maximum area under the curve for overall DCP VD in the macula was 0.707, with a cutoff value of 19.64, sensitivity of 65.30%, and specificity of 73.50%. In CHD group, Pearson correlation analysis demonstrated a negative correlation between the Gensini score and mean DCP VD (r = - 0.491, P < 0.001). Retinal VD in patients requiring revascularization for CHD is significantly lower compared to healthy controls. SS-OCTA-based retinal microvascular damage assessment is a valuable tool for risk stratification and early intervention in CHD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.