Evidence map›Paper›PMID 39738571›Full record

ReviewAbdominal radiology (New York)2025

AI-Driven insights in pancreatic cancer imaging: from pre-diagnostic detection to prognostication.

Ajith Antony, Sovanlal Mukherjee, Yan Bi, Eric A Collisson, Madhu Nagaraj, Murlidhar Murlidhar, Michael B Wallace, Ajit H Goenka

Abstract readReview
In one paragraph

Review in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ajith AntonyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Sovanlal MukherjeeDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Yan BiDepartment of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
Eric A CollissonDepartment of Medical Oncology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Madhu NagarajDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Murlidhar MurlidharDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Michael B WallaceDepartment of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
Ajit H GoenkaDepartment of Radiology, Mayo Clinic, Rochester, MN, USA. goenka.ajit@mayo.edu.

Funding

Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid BiopsyR01CA256969 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Collisson, Ajit Harishkumar Goenka · 2021 to 2026
$3.1M
Quantitative In Vivo 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 PET Imaging of Cancer-Associated Fibroblasts (CAFs) in Pancreatic Ductal Adenocarcinoma (PDA)R01CA272628 · NCI · MAYO CLINIC ROCHESTER · PI GOENKA, AJIT HARISHKUMAR · 2022 to 2025
$2.5M
Optimizing Treatment Approaches to Lung Cancers Harboring MET Exon 14 mutationsR01CA239604 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLISSON, ERIC · 2019 to 2023
$2.0M
Centene Charitable Foundation N/AChampions for Hope Pancreatic Cancer Research Program of the Funk Zitiello Foundation N/AHoveida Family Foundation N/AMayo Clinic Comprehensive Cancer Center N/ANCI NIH HHS R01 CA239604NCI NIH HHS R01 CA256969NCI NIH HHS R01 CA272628NIH HHS R01CA256969
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States, largely due to its poor five-year survival rate and frequent late-stage diagnosis. A significant barrier to early detection even in high-risk cohorts is that the pancreas often appears morphologically normal during the pre-diagnostic phase. Yet, the disease can progress rapidly from subclinical stages to widespread metastasis, undermining the effectiveness of screening. Recently, artificial intelligence (AI) applied to cross-sectional imaging has shown significant potential in identifying subtle, early-stage changes in pancreatic tissue that are often imperceptible to the human eye. Moreover, AI-driven imaging also aids in the discovery of prognostic and predictive biomarkers, essential for personalized treatment planning. This article uniquely integrates a critical discussion on AI's role in detecting visually occult PDAC on pre-diagnostic imaging, addresses challenges of model generalizability, and emphasizes solutions like standardized datasets and clinical workflows. By focusing on both technical advancements and practical implementation, this article provides a forward-thinking conceptual framework that bridges current gaps in AI-driven PDAC research.

Indexed as

Artificial IntelligenceCarcinoma, Pancreatic DuctalImage Interpretation, Computer-AssistedPancreatic NeoplasmsEarly Detection of CancerHumansPrognosisArtificial intelligenceBiomarkersComputed tomographyDetectionPancreasPancreatic ductal adenocarcinomaPrognosticationSegmentation

Identifiers

PMID39738571
PMCPMC12352131

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.