ArticleCell biochemistry and biophysics2025
Cardioprotective Potential of d-limonene against Isoproterenol induced Myocardial Infarction in Rats.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Dynamic changes in OTULIN and progranulin levels in experimental myocardial infarction and cardiac remodeling.Histochemistry and cell biology · 2026Article
- Lipid Modifications and Inflammation in Cardiometabolic and Vascular Disease: Perspectives from a Special Edition Honoring a Pioneer Scientist.Cell biochemistry and biophysics · 2026Article
- Cardioprotective Potential ofCurrent drug targets · 2026Article
- Valorisation of citrus peels: implications for cardiovascular diseases and diabetes management.Inflammopharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
d-limonene is a type of colorless liquid hydrocarbon that falls under the category of cyclic monoterpene. It is the component found in the oil extracted from fruit peels. Isoproterenol, a synthetic β-adrenergic agonist, was administered to rats to induce myocardial injury by increasing heart rate and myocardial oxygen demand, leading to ischemia and oxidative stress. This study aims to investigate the properties of d limonene, against myocardial infarction induced by isoprenaline (ISO) in rats. Male Sprague Dawley rats were treated with d-limonene (200 & 400 mg/kg, p.o) daily for 28 days and administered ISO (85 mg/kg, s.c) on the 29th and 30th days at an interval of 24 hr to induce myocardial injury. Morphological and antioxidant parameters, biochemical markers, lipid profile, troponin-I, cardiac ATPase, heart mitochondrial, and lysosomal enzymes were assayed followed by histopathological screening. Rats treated with isoproterenol (85 mg/kg, s.c), administered twice at an interval of 24 h on 29th and 30th day showed a significant change in morphological and antioxidant parameters, biochemical markers, lipid profile, troponin-I, cardiac ATPase, heart mitochondrial, lysosomal enzymes activities and transcription factor (TNF-α/IL-6/NF-kB) expression. Pretreatment with d-limonene (200 and 400 mg/kg, p.o) for 28 days followed by ISO administration on 29
Indexed as
Identifiers
39738843What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.