Evidence map›Paper›PMID 39738864›Full record

Observational studyEuropean journal of applied physiology2025

Effect of eccentric-based resistance exercise on bone (re)modelling markers across the menstrual cycle and oral contraceptive cycle.

Isabel Guisado-Cuadrado, Nuria Romero-Parra, Rocío Cupeiro, Kirsty J Elliott-Sale, Craig Sale, Ana B Peinado

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04458662 (Iron and Muscular Damage), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04458662 completednot on this map

Iron and Muscular Damage: FEmale Metabolism and Menstrual Cycle During Exercise

Typeobservational_patient_registrySponsorUniversidad Politecnica de MadridRan2017 to 2020Enrolled103ConditionsIron-deficiency, Inflammation, Exercise Induced Iron-deficiency, Exercise Induced Muscle DamageArmsInterval running protocol / eccentric-based resistance exercise protocol
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabel Guisado-CuadradoLFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain. i.guisadoc@upm.es.ORCID https://orcid.org/0000-0002-1767-5341
Nuria Romero-ParraLFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0001-9754-5565
Rocío CupeiroLFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0002-4119-0002
Kirsty J Elliott-SaleDepartment of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK.ORCID http://orcid.org/0000-0003-1122-5099
Craig SaleDepartment of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK.ORCID http://orcid.org/0000-0002-5816-4169
Ana B PeinadoLFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0002-4871-8682

Funding

Ministerio de Economía y Competitividad DEP2016-75387-P
6 · The paper itself

Abstract

purposeTo investigate the acute effects of eccentric-based resistance exercise and sex-hormone fluctuations on P1NP and β-CTX-1 concentrations in premenopausal females.

methodsNine eumenorrheic females and ten oral contraceptive (OC) users performed eccentric-based resistance exercise, consisted of 10 × 10 repetitions of parallel back squats with a 4-s eccentric phase, in the early-follicular (EFP), late-follicular (LFP) and mid-luteal (MLP) phases of the menstrual cycle (MC) or in the withdrawal (WP) and active pill-taking (APP) phases of the OC cycle.

results17β-oestradiol (pg·ml

conclusionsβ-CTX-1 concentrations were lower in the mid-luteal phase, emphasising the importance of standardizing bone marker measurements to a specific MC phase. OC users exhibited reduced P1NP levels, underscoring the need to investigate synthetic and endogenous hormones' impact on long-term bone structure and strength. Trial registration The study was registered at Clinicaltrials.gov NCT04458662 on 2 July 2020.

Indexed as

Bone RemodelingContraceptives, OralMenstrual CycleResistance TrainingAdultBiomarkersCollagen Type IEstradiolFemaleHumansPeptide FragmentsPeptidesProcollagenProgesteroneYoung AdultBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideContraceptives, OralEstradiolPeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideProgesteroneOestradiolP1NPProgesteroneSex hormonesTrainingβ-CTX

Identifiers

PMID39738864

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.