ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Mild Hyperthermia Accelerates Bone Repair by Dynamically Regulating iNOS/Arg1 Balance in the Early Stage.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bioelectric signals promote diabetic bone regeneration through Piezo1-mediated activation of the efferocytic immune microenvironment.Bioactive materials · 2026Article
- LIPUS combined with mild hyperthermia promotes rotator cuff healing via TRPV1/CaJournal of orthopaedic translation · 2026Article
- Enhancing Bone Repair Process: Application and Perspective on Photothermal Materials.Molecules (Basel, Switzerland) · 2026Review
- Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration.Bioactive materials · 2026Review
- Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants.Materials today. Bio · 2026Article
- Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.Allergy · 2026Article
- Chrysanthemum indicum L.-derived extracellular vesicles enhance the therapeutic efficacy of cyclosporine a against dry eye disease.Journal of nanobiotechnology · 2026Article
- Nanomaterial-Based Photothermal Therapy for Inflammatory Diseases: Intervention Strategies, Synergistic Effects, and Future Challenges.International journal of nanomedicine · 2026Review
- Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis.Theranostics · 2026Article
- From suspected necrotizing fasciitis to diagnosed drug-induced fever: a diagnostic maze and reflections on anti-infection management in a case of postoperative fever after femoral fracture.Frontiers in medicine · 2026Article
- Ultrasound-Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the "Two-Way Regulation" Bone Homeostasis Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering.ACS applied materials & interfaces · 2025Article
- Mild Hyperthermia Accelerates Bone Repair by Dynamically Regulating iNOS/Arg1 Balance in the Early Stage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Macrophage polarization: molecular mechanisms, disease implications, and targeted therapeutic strategies.Frontiers in immunology · 2025Review
- Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization.Biomaterials research · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Mild hyperthermia therapy has garnered interest as an adjunctive treatment for bone repair. However, its optimal timing, duration, and underlying mechanisms remain unclear. In this study, how mild hyperthermia supports bone repair during the early stages is assesed. These findings reveal that mild hyperthermia accelerates bone regeneration by dynamically regulating inducible nitric oxide synthase/arginase 1 (iNOS/Arg1) balance. This process involves macrophage polarization to the M1 phenotype through iNOS activation, followed by a rapid transition to the M2 phenotype through Arg1 activation after 3 days of sustained mild hyperthermia. RNA-Seq reveals that a single day of mild hyperthermia induced immune alterations aligned with the early inflammatory phase of bone repair, characterized by osteoclast activation, cell recruitment, and neovascularization, thereby preparing for the transition to the repair phase. Experiments involving subcutaneous abscesses, subcutaneous embedding, and critical cranial bone defects further confirm that early mild hyperthermia treatment dynamically regulates macrophage phenotypes. This regulation enhances early antibacterial activity, promotes angiogenesis, and facilitates the transition from inflammation to repair, ultimately accelerating bone-defect repair. This study is the first to elucidate the dual temporal effects of early mild hyperthermia on immune regulation, offering insights into the optimal timing and duration of photothermal therapy following bone repair surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.