Evidence map›Paper›PMID 39739031›Full record

ArticleArchives of toxicology2025

Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice.

Sarah McCarrick, Vilhelm Malmborg, Louise Gren, Pernille Høgh Danielsen, Martin Tunér, Lena Palmberg, Karin Broberg, Joakim Pagels, Ulla Vogel, Anda R Gliga

Abstract read
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah McCarrickInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Vilhelm MalmborgDivision of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden.
Louise GrenDivision of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden.
Pernille Høgh DanielsenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Martin TunérDivision of Combustion Engines, Lund University, Lund, Sweden.
Lena PalmbergInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karin BrobergInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Joakim PagelsDivision of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden.
Ulla VogelNational Research Centre for the Working Environment, Copenhagen, Denmark.
Anda R GligaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. anda.gliga@ki.se.ORCID 0000-0003-2775-1632

Funding

Svenska Forskningsrådet Formas 2021-01406Svenska Forskningsrådet Formas 2021-02010
6 · The paper itself

Abstract

Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum diesel with renewable diesel can alter emission properties but the potential health effects remain unclear. This study aimed to explore toxicity and underlying mechanisms of diesel exhaust from renewable fuels. Using proximity extension assay (Olink), 92 proteins linked to inflammation, cardiovascular function, and cancer were analyzed in bronchoalveolar lavage fluid (BALF) and plasma in mice 1 day after pulmonary exposure to exhaust particles at doses of 6, 18, and 54 µg/mouse. Particles were generated from combustion of renewable (rapeseed methyl ester, RME13, hydrogen-treated vegetable oil, HVO13; both at 13% O

Indexed as

Air PollutantsBronchoalveolar Lavage FluidLungParticulate MatterVehicle EmissionsAnimalsDose-Response Relationship, DrugFemaleInhalation ExposureMaleMiceMice, Inbred C57BLAir PollutantsParticulate MatterVehicle EmissionsCytokinesDiesel exhaust particlesIntratracheal instillationLung inflammationProtein profileRenewable fuelsSystemic effects

Identifiers

PMID39739031
PMCPMC11775017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.