Evidence map›Paper›PMID 39739369›Full record

ArticlePhysiological reports2025

Oral administration of pioglitazone inhibits pulmonary hypertension by regulating the gut microbiome and plasma metabolome in male rats.

Zizhou Zhang, Yaru Liang, Shaocong Mo, Mingming Zhao, Yi Li, Chenting Zhang, Xiaoqian Shan, Shiyun Liu, Jing Liao, Xiaoyun Luo and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zizhou ZhangDepartment of Laboratory Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, China.
Yaru LiangDepartment of Laboratory Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, China.
Shaocong MoDepartment of Laboratory Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, China.
Mingming ZhaoState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Yi LiState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chenting ZhangState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaoqian ShanState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Shiyun LiuState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jing LiaoState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaoyun LuoState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Junqi ZhuState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chen WangState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Qian JiangState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chi HouState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Wei HongGMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
Ning LaiState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Yuqin ChenState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Lei XuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Wenju LuState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jian WangState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-1278-256X
Zhongfang WangState Key Laboratory of Respiratory Disease, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-3236-5170
Kai YangDepartment of Laboratory Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, China.ORCID https://orcid.org/0000-0003-3044-2240

Funding

National Natural Science Foundation of China (NSFC) 82170065National Natural Science Foundation of China (NSFC) 82241012
6 · The paper itself

Abstract

The oral administrated thiazolidinediones (TZDs) have been widely reported to alleviate experimental pulmonary hypertension (PH). However, previous studies mainly focused on their beneficial effects on the cardiopulmonary vascular system but failed to determine their potential roles on gut microenvironment. This study aims to investigate the effects of pioglitazone, an oral TZD drug, on gut microbiome in classic PH rat models induced by hypoxia (HPH) or SU5416/hypoxia (SuHx-PH) and evaluate the therapeutic potential of supplementation of selective probiotics for experimental PH. Pioglitazone remarkably inhibited the PH pathogenesis in both models and reshaped the gut microbiome and plasma metabolome. Correlation analyses represented strong and unique association between the protective metabolites and bacteria genera (Roseburia, Lactobacillus, and Streptococcus) that were positively stimulated by pioglitazone. Supplementation of selective probiotics Roseburia intestinalis (R. intestinalis) partially attenuated SuHx-PH and rebuilt a novel gut microbiome and host metabolome. This study reports for the first time that oral administration of pioglitazone protects PH by regulating the gut microbiome and host metabolome, providing novel insights for the TZD drugs. The data also supports that modulation of gut microbiota by supplementation of selective probiotics could be a novel effective therapeutic strategy for the treatment of PH.

Indexed as

Gastrointestinal MicrobiomeHypertension, PulmonaryMetabolomePioglitazoneProbioticsRats, Sprague-DawleyAdministration, OralAnimalsHypoxiaIndolesMalePyrrolesRatsIndolesPioglitazonePyrrolesSemaxinibgut microbiomeperoxisome proliferator‐activated receptor gammapioglitazoneplasma metabolomepulmonary hypertension

Identifiers

PMID39739369
PMCPMC11685845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.