Evidence map›Paper›PMID 39739816›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.

Razan A Fakieh, David J Reiner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. RAP-2-independent roles formicroPublication biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Razan A FakiehDepartment of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Texas A&M University, Houston, TX 77030.ORCID 0000-0002-3511-2665
David J ReinerDepartment of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Texas A&M University, Houston, TX 77030.ORCID 0000-0002-0344-7161

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Understanding Ras effector switching and roles of Ras>RalGEF>Ral in developmentR35GM144237 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI David Reiner · 2022 to 2026
$1.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM144237MOE | Saudi Arabian Cultural Mission (SACM) 1007758160NIGMS NIH HHS R35 GM144237NIH HHS P40 OD010440
6 · The paper itself

Abstract

Induction of cell fates by growth factors impacts many facets of developmental biology and disease. LIN-3/EGF induces the equipotent vulval precursor cells (VPCs) in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans Proteinsras ProteinsReceptors, NotchVulvaAnimalsCell DifferentiationEpitheliumFemaleSignal TransductionCaenorhabditis elegans Proteinslet-60 protein, C elegansras ProteinsReceptors, NotchACDS-10citron NIK1 homologyLET-60LIN-12Rap2

Identifiers

PMID39739816
PMCPMC11725784

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.