Trial reportThe Australian & New Zealand journal of obstetrics & gynaecology2025
Does Antenatal Expressing Affect Onset of Lactogenesis for Women With Diabetes? Results From a Randomised Controlled Trial and Cohort Study.
Trial report in The Australian & New Zealand journal of obstetrics & gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of antenatal breast milk expression on maternal and infant outcomes: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Information and practices of antenatal colostrum expression: a cross-sectional study of pregnant women in Norway.BMC pregnancy and childbirth · 2026Article
- Antenatal colostrum expression: are we interfering with nature?International breastfeeding journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPreviously it was recognised onset of Lactogenesis II was delayed in women with Type I diabetes compared to women without diabetes, but the effect of gestational diabetes was unclear. Some clinicians suggest pregnant women with diabetes express breastmilk in late pregnancy to hasten onset of Lactogenesis II.
aimsTo confirm if Lactogenesis II occurs later in women with diabetes in pregnancy, and test if advice to express antenatally hastens Lactogenesis II. MATERIALS AND
methodsData from the DAME (Diabetes Antenatal Milk Expression) randomised controlled trial collected at recruitment and 2 weeks postpartum were compared with a concurrent purposively recruited cohort of women without diabetes in pregnancy. Timing of lactogenesis and adjusted percentage differences were calculated. Study sample was women from both studies with complete data for included measures to assess onset of Lactogenesis II (maternal perception).
resultsDelayed onset of lactation (≥ 72 h postpartum) was similar in DAME trial arms: standard care 58.6% (143/244); antenatal expressing 55.8% (148/265) but lower in comparison cohort 46.9% (90/192). Percentage difference between groups (adjusted for parity, delivery mode, BMI and gestation): DAME standard arm and comparison cohort 12.3% (95% CI 2.6%-22.0%; p = 0.01) DAME intervention arm and comparison cohort 8.3% (95% CI -1.2%-17.8%; p = 0.09) DAME standard care and intervention 4.0% (95% CI -4.5%-12.5%; p = 0.35).
conclusionsLactogenesis II occurs later for women with diabetes in pregnancy than women without diabetes. Our findings do not provide evidence that antenatal expressing hastens onset of lactation in women with diabetes in pregnancy.
trial registrationClinicalTrials.gov identifier: ACTRN12611000217909.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.