Evidence map›Paper›PMID 39740916›Full record

ArticleIn vivo (Athens, Greece)

Identification of a T2-hyperintense Perivascular Space in Brain Arteriovenous Malformations.

Thomas Wälchli, Kartik Dev Bhatia, Will Guest, Jeroen Bisschop, Leonardo Olijnyk, Hans Kortman, Paul E Constanthin, Patrick Nicholson, Philippe P Monnier, Aristotelis Kalyvas and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Glymphatic System and Its Role in Neurovascular Diseases.Journal of neuroendovascular therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thomas Wälchli *Group Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada; thomas.waelchli2@uzh.ch.
Kartik Dev BhatiaDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada.
Will GuestDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada.
Jeroen BisschopGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.
Leonardo OlijnykGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.
Hans KortmanDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada.
Paul E ConstanthinDepartment of Neurosurgery, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Patrick NicholsonDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada.
Philippe P MonnierDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Aristotelis KalyvasAttikon Hospital, Department of Neurosurgery, National and Kapodistrian University of Athens, Athens, Greece.
Ethan A WinklerDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Moncef BerhoumaDepartment of Neurosurgery, University Hospital of Dijon, Bourgogne, France.
Timo KringsDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, ON, Canada.
Ivan Radovanovic *Group Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada; ivan.radovanovic@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimBrain arteriovenous malformations (AVMs) are vascular malformations characterized by dysmorphic, aberrant vasculature. During previous surgeries of compact nidus brain AVMs (representing the majority of cases), we have observed a "shiny" plane between nidal and perinidal AVM vessels and the surrounding grey and white matter and hypothesized that preoperative neuroimaging of brain AVMs may show a neuroradiological correlate of these intraoperative observations. PATIENTS AND

methodsWe retrospectively reviewed and analyzed multiplanar and multisequence 3-Tesla magnetic resonance (3T MR) imaging in five consecutive brain AVMs with special attention on imaging characteristics of the brain-AVM interface, i.e., the perivascular and perinidal regions.

resultsIn all five patients, we identified T2-hypertinense perivascular perinidal spaces, which were predominantly observed around the AVM nidus and less prominently around the feeding arteries or draining veins.

conclusionThe identification of T2-hypertinense perivascular spaces surrounding brain AVMs on neuroradiological imaging may provide insights into the anatomico-radiological relationships of brain AVMs and the surrounding grey and white matter parenchyma. These findings could have future implications for our understanding of brain AVM biology and may influence neurosurgical approaches to these lesions.

Indexed as

Intracranial Arteriovenous MalformationsMagnetic Resonance ImagingAdultBrainFemaleHumansMaleMiddle AgedRetrospective StudiesBrain AVMsneuroradiological characterizationperivascular (perinidal) spaceT2-hyperintense perivascular rim around AVM nidusVirchow-Robin space

Identifiers

PMID39740916
PMCPMC11705134

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.