Evidence map›Paper›PMID 39741321›Full record

ArticleJournal of translational medicine2024

Gut microbial 'TNFα-sphingolipids-steroid hormones' axis in children with autism spectrum disorder: an insight from meta-omics analysis.

Li Shao, Guangyong Cai, Jinlong Fu, Weishi Zhang, Yuefang Ye, Zongxin Ling, Shiwei Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Observational
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li ShaoSchool of Clinical Medicine, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Guangyong CaiDepartment of Acupuncture and Chinese Tuina, Lishui Second People's Hospital, Lishui, Zhejiang, 323000, China.
Jinlong FuSchool of Clinical Medicine, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Weishi ZhangDepartment of Otolaryngology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, 226001, China.
Yuefang YeSchool of Clinical Medicine, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Zongxin LingState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China. lingzongxin_lzx@163.com.
Shiwei YeLishui Key Laboratory of mental Health and brain Disorders, Lishui Second People's Hospital, Lishui, Zhejiang, 323000, China. yeshiwei@163.com.

Funding

National Natural Science Foundation of China 31870839Natural Science Foundation of Zhejiang Province LY22C010001Zhejiang Provincial Medical and Health Science and Technology Plan 2022KY1451Zhejiang Provincial Medical and Health Science and Technology Plan 2022KY971
6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) is a persistent neurodevelopmental disorder affecting brains of children. Mounting evidences support the associations between gut microbial dysbiosis and ASD, whereas detailed mechanisms are still obscure.

methodsHere we probed the potential roles of gut microbiome in ASD using fecal metagenomics and metabolomics.

resultsChildren with ASD were found to be associated with augmented serum cytokines milieu, especially TNFα. Metagenomic analysis generated 29 differential species and 18 dysregulated functional pathways such as Bifidobacterium bifidum, Segatella copri, and upregulated 'Sphingolipid metabolism' in children with ASD. Metabolomics revealed steroid hormone dysgenesis in children with ASD with lower abundances of metabolites such as estriol, estradiol and deoxycorticosterone. A three-way association analysis showed positive correlations between TNFα and microbial function potentials such as 'Bacterial toxins' and 'Lysosome', indicating the contribution of microbial dysbiosis to neuroinflammation. TNFα also correlated positively with 'Sphingolipid metabolism', which further showed negative correlations with metabolites estriol and deoxycorticosterone. Such results, in consistent with current findings, revealed the contribution of increased TNFα to upregulated sphingolipid metabolism, which further impaired steroid hormone biosynthesis.

conclusionOur study proposed the gut microbial 'TNFα-sphingolipids-steroid hormones' axis in children with ASD, which may provide new perspectives for developing gut microbiome-based treatments in the future.

Indexed as

Autism Spectrum DisorderGastrointestinal MicrobiomeSphingolipidsSteroidsTumor Necrosis Factor-alphaChildChild, PreschoolDysbiosisFecesFemaleHormonesHumansMaleMetabolomicsMetagenomicsHormonesSphingolipidsSteroidsTumor Necrosis Factor-alphaautism spectrum disordergut microbiomemetabolomicsmetagenomics

Identifiers

PMID39741321
PMCPMC11687191

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.