Evidence map›Paper›PMID 39742340›Full record

ArticleJournal of biotechnology and biomedicine2024

Cellular and Molecular Mechanisms and Innovative Neurostimulation Treatments in the Management of Traumatic Brain Injury.

Arnav Aggarwal, Yssel Mendoza-Mari, Devendra K Agrawal

Abstract read
In one paragraph

Article in Journal of biotechnology and biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Limitations of Current Therapies and Barriers in Alzheimer's Disease.Archives of internal medicine research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Isolation of Primary Brain Cells: Challenges and Solutions.Archives of clinical and biomedical research · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arnav AggarwalLoveless Academic Magnet Program, Montgomery, AL, USA.
Yssel Mendoza-MariDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Devendra K AgrawalDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.

Funding

Novel Approach to Stabilize Atherosclerotic Plaque in Carotid ArteryR01HL144125 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2018 to 2021
$2.8M
Novel Molecular Target to Prevent Maturation Failure of Arteriovenous FistulaR01HL147662 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2019 to 2022
$2.8M
NHLBI NIH HHS R01 HL144125NHLBI NIH HHS R01 HL147662
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is one of the growing public health problems and a leading cause of disabilities and mortality worldwide. After the mechanical impact to the head, patients of all ages suffer from cognitive and neurological deficits, as well as psychological disorders to different extents. In the last years, the use of electrical impulses and magnetic currents to achieve therapeutic effects have shown promising results and became potential treatments for TBI. Potential mechanisms of action described so far include long term potentiation and depression of neuronal synapses, stimulation of neurotransmitters and growth factors release, and reduction of neuroinflammation, apoptosis and excitotoxicity, among others. Although promising results have been obtained in pre-clinical experiments and limited clinical studies, the high rate of variability in technical parameters and the limited number of patients enrolled have made difficult to clearly define the optimal conditions to obtain reliable therapeutic effects with these stimulation techniques in TBI patients. The present review aims to describe the molecular processes taking place in the brain after the injury, as well as to describe some of the neurostimulation treatments currently under development for TBI management.

Indexed as

Deep brain stimulationPulsed electromagnetic field stimulationTranscranial direct current stimulationTranscranial magnetic stimulationTraumatic brain injury

Identifiers

PMID39742340
PMCPMC11687385

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.