Evidence map›Paper›PMID 39742687›Full record

ArticleJournal of the mechanical behavior of biomedical materials2025

Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions.

Collin E Haese, Vijay Dubey, Mrudang Mathur, Alison M Pouch, Tomasz A Timek, Manuel K Rausch

Abstract read
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In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Collin E HaeseDepartment of Mechanical Engineering, The University of Texas at Austin, 204 E. Dean Keeton Street, Austin, TX, 78712, USA.
Vijay DubeyDepartment of Mechanical Engineering, The University of Texas at Austin, 204 E. Dean Keeton Street, Austin, TX, 78712, USA.
Mrudang MathurDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd Extension, Palo Alto, CA, 94304, USA.
Alison M PouchDepartment of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Tomasz A TimekDivision of Cardiothoracic Surgery, Corewell Health West, Michigan State University College of Human Medicine, 100 Michigan Ave SE, Grand Rapids, MI, 49503, USA.
Manuel K RauschDepartment of Mechanical Engineering, The University of Texas at Austin, 204 E. Dean Keeton Street, Austin, TX, 78712, USA; Department of Aerospace Engineering & Engineering Mechanics, The University of Texas at Austin, 2617 Wichita Street, Austin, TX, 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street, Austin, TX, 78712, USA; The Oden Institute for Computational Engineering & Sciences, The University of Texas at Austin, 201 E. 24th Street, Austin, TX, 78712, USA. Electronic address: manuel.rausch@utexas.edu.

Funding

Using an Electrospun Surrogate Model to Investigate Mechanisms of Tricuspid Valve MaladaptationR01HL165251 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI MANUEL Karl RAUSCH · 2022 to 2026
$4.3M
Human-Specific Prediction, Training, and Visualization Tools for the Tricuspid Valve from Existing DataR21HL161832 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI RAUSCH, MANUEL KARL · 2022 to 2023
$222k
NHLBI NIH HHS R01 HL165251NHLBI NIH HHS R21 HL161832
6 · The paper itself

Abstract

Transcatheter edge-to-edge repair (TEER) simulations may provide insight into this novel therapeutic technology and help optimize its use. However, because of the relatively short history and technical complexity of TEER simulations, important questions remain unanswered. For example, there is no consensus on how to handle the annular boundary conditions in these simulations. In this short communication, we tested the sensitivity of such simulations to the choice of annular boundary conditions using a high-fidelity finite element model of a human tricuspid valve. Therein, we embedded the annulus among elastic springs to simulate the compliance of the perivalvular myocardium. Next, we varied the spring stiffness parametrically and explored the impact on two key measures of valve function: coaptation area and leaflet stress. Additionally, we compared our results to simulations with a pinned annulus. We found that a compliant annular boundary condition led to a TEER-induced "annuloplasty effect," i.e., annular remodeling, as observed clinically. Moreover, softer springs led to a larger coaptation area and smaller leaflet stresses. On the other hand, pinned annular boundary conditions led to unrealistically high stresses and no "annuloplasty effect." Furthermore, we found that the impact of the boundary conditions depended on the clip position. Our findings in this case study emphasize the importance of the annular boundary condition in tricuspid TEER simulations. Thus, we recommend that care be taken when choosing annular boundary conditions and that results from simulations using pinned boundaries should be interpreted with caution.

Indexed as

Finite Element AnalysisMechanical PhenomenaModels, CardiovascularTricuspid ValveBiomechanical PhenomenaHumansStress, Mechanical

Identifiers

PMID39742687
PMCPMC11959512

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.