Evidence map›Paper›PMID 39743402›Full record

ReviewTrends in endocrinology and metabolism: TEM2025

Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.

Julia An, Ariel S Thorson, David H Wasserman, John M Stafford, Lin Zhu

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia AnDepartment of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Ariel S ThorsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Tennessee Valley Health System, Veterans Affairs, Nashville, TN, USA.
David H WassermanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
John M StaffordDepartment of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Tennessee Valley Health System, Veterans Affairs, Nashville, TN, USA.
Lin ZhuDepartment of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Tennessee Valley Health System, Veterans Affairs, Nashville, TN, USA. Electronic address: lin.zhu@vumc.org.

Funding

Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Sex-Specific Risk of Metabolic and Cardiovascular DiseaseR01HL144846 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Michael Stafford · 2019 to 2026
$4.1M
Therapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular RiskR01DK109102 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STAFFORD, JOHN MICHAEL · 2016 to 2024
$3.6M
Does Senescence Impair the Cardiovascular Benefits of Menopause Hormone Therapy?K01AG077038 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lin Zhu · 2022 to 2026
$601k
Cholesteryl ester transfer protein, a novel mediator of insulin sensitivityI01BX002223 · VA · VETERANS HEALTH ADMINISTRATION · PI STAFFORD, JOHN MICHAEL · 2014 to 2017
–
BLRD VA I01 BX002223NHLBI NIH HHS R01 HL144846NIA NIH HHS K01 AG077038NIDDK NIH HHS R01 DK109102NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

Premenopausal women and endurance-trained individuals of either sex have reduced cardiovascular disease (CVD) risk. Endurance training shifts fuel selection towards fats to spare carbohydrates; interestingly, women prioritize fats as an energy resource more than men do during exercise. Relying on fats during exercise drives whole-body lipolysis and promotes lipid uptake and oxidation capacity in skeletal muscles. These metabolic adaptations during exercise result in protection against diet-induced obesity, a healthy body fat distribution, and reduced plasma triacylglycerol (TG) concentrations. Here, we analyze how sex differences and endurance training mediate changes in skeletal muscles, including exercise-induced lipolysis, lipid uptake and β-oxidation, intramuscular TG storage, and postexercise lipid metabolism, and discuss how regulating this processes affects CVD risk.

Indexed as

Cardiovascular DiseasesEndurance TrainingExerciseLipid MetabolismAnimalsFemaleHumansMaleMuscle, SkeletalSex CharacteristicsCVD riskendurance trainingintramyocellular triacylglycerol (IMTG)muscle fiber typespost-exercise recoverysex differences in fuel selection

Identifiers

PMID39743402
PMCPMC12206935

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.