Evidence map›Paper›PMID 39743553›Full record

ArticleBMC nephrology2025

Analysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing hemodialysis.

Agnieszka Turoń-Skrzypińska, Alicja Mińko, Aleksandra Rył, Aneta Cymbaluk-Płoska, Maciej Domański, Kazimierz Ciechanowski, Iwona Rotter

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Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agnieszka Turoń-SkrzypińskaDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.
Alicja MińkoDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland. alicja.minko287@gmail.com.
Aleksandra RyłDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.
Aneta Cymbaluk-PłoskaDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Powstańców Wielkopolskich 72, Szczecin, 70- 111, Poland.
Maciej DomańskiDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wielkopolskich 72, Szczecin, 70-111, Poland.
Kazimierz CiechanowskiDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wielkopolskich 72, Szczecin, 70-111, Poland.
Iwona RotterDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe problem of reduced physical activity in patients with stage 5 Chronic Kidney Disease (CKD) is becoming more and more interesting in the medical community. One of the innovative solutions that can significantly increase patients' motivation to exercise is the integration of physical training with virtual reality (VR) technology during hemodialysis. The aim of this study was to comprehensively assess the impact of regular physical activity using virtual reality on the concentration of plasma PCSK9 protein and TNF-α in patients with stage 5 CKD treated with hemodialysis.

methodsA prototype of the NefroVR system was used in the research project. The study group consisted of patients who were entrusted with the task of conducting training using the prototype of the NefroVR system.

resultsIn the conducted research, a significant decrease in PCSK9 protein and TNF-α concentration was observed in the study group after 3 months of exercises using virtual reality in hemodialysis patients.

conclusionRegular physical activity using innovative physiotherapy methods, such as virtual reality, contributes to the improvement of inflammatory parameters and may improve lipid homeostasis. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

Proprotein Convertase 9Renal DialysisTumor Necrosis Factor-alphaVirtual RealityAdultAgedExerciseExercise TherapyFemaleHumansKidney Failure, ChronicMaleMiddle AgedRenal Insufficiency, ChronicPCSK9 protein, humanProprotein Convertase 9Tumor Necrosis Factor-alphaCytokineHemodialysisIntradialytic exerciseRenal diseaseVirtual reality

Identifiers

PMID39743553
PMCPMC11694471

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.