Evidence mapPaperPMID 39745314Full record

ReviewDevelopment (Cambridge, England)2025

A comparative view of human and mouse telencephalon inhibitory neuron development.

Changuk Chung, Joseph Girgiss, Joseph G Gleeson

Abstract readReviewComparative Study
In one paragraph

Review in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Changuk ChungDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0000-0003-3628-6090
Joseph GirgissDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-0889-9220
Joseph G GleesonDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92037, USA.

Funding

Origins of Brain Somatic Mosaicism in Developmental Brain DiseaseR01MH124890 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$303k
Larry L. Hillblom FoundationNIMH NIH HHS R01 MH124890NIMH NIH HHS U01 MH108898NIMH NIH HHS U01MH108898
6 · The paper itself

Abstract

Human GABAergic inhibitory neurons (INs) in the telencephalon play crucial roles in modulating neural circuits, generating cortical oscillations, and maintaining the balance between excitation and inhibition. The major IN subtypes are based on their gene expression profiles, morphological diversity and circuit-specific functions. Although previous foundational work has established that INs originate in the ganglionic eminence regions in mice, recent studies have questioned origins in humans and non-human primates. We review the origins of INs in mice and compare with recent findings from primary human prenatal brain tissue culture experiments and lineage analysis from somatic variants in neurotypical human cadavers and human brain organoids. Together, these studies suggest potential primate- or human-specific processes that may have been overlooked in mouse models and could have implications for brain disorders.

Indexed as

GABAergic NeuronsTelencephalonAnimalsHumansMiceNeurogenesisNeuronsBrain disorderEvolutionInhibitory neuronNeurodevelopmentOrigin

Identifiers

PMID39745314
PMCPMC11829773

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.