Evidence map›Paper›PMID 39745377›Full record

ArticleAntimicrobial agents and chemotherapy2025

Reactivation of hidden-latent

Eugenia Sancho-Sánchez, Kimberly García-Arteaga, Fabio Granados-Chinchilla, Graciela Artavia, Alejandro Alfaro-Alarcón, Andrés Villalobos-Villalobos, Laura Bouza-Mora, Marcela Suárez-Esquivel, Carlos Chacón-Díaz, Caterina Guzmán-Verri and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pathogenicity ofTropical medicine and infectious disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eugenia Sancho-SánchezPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Kimberly García-ArteagaPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Fabio Granados-ChinchillaCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
Graciela ArtaviaCentro Nacional de Ciencia y Tecnología de Alimentos, Universidad de Costa Rica, San José, Costa Rica.
Alejandro Alfaro-AlarcónDepartamento de Patología, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Andrés Villalobos-VillalobosDepartamento de Análisis Clínicos, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Laura Bouza-MoraDepartamento de Análisis Clínicos, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Marcela Suárez-EsquivelPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Carlos Chacón-DíazCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.ORCID 0000-0003-0865-0772
Caterina Guzmán-VerriPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Edgardo MorenoPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.ORCID 0000-0001-8771-3959
Elías Barquero-CalvoPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.ORCID 0000-0003-4428-3340

Funding

Consejo Nacional de Rectores (CONARE) 803-C2-651
6 · The paper itself

Abstract

Brucellosis has therapeutic challenges due to 3%-15% relapses/therapeutic failures (R/TF) after antibiotic treatment. Therefore, determining the antibiotic concentration in tissues, the physiopathological parameters, and the R/TF after treatment is relevant. After exploring different antibiotic quantities, we found that a combined dose of 100 µg/g of doxycycline (for 45 days) and 7.5 µg/g of streptomycin (for 14 days), respectively, achieved therapeutic levels of more than fourfold minimum inhibitory concentrations (MICs) against

Indexed as

Anti-Bacterial AgentsBrucella abortusBrucellosisDoxycyclineStreptomycinAnimalsFemaleLiverMiceMice, Inbred BALB CMicrobial Sensitivity TestsSpleenAnti-Bacterial AgentsDoxycyclineStreptomycinantibiotic resistanceantibiotic treatmentbrucellosiscytokinesdoxycyclineINF-γrelapsesstreptomycin

Identifiers

PMID39745377
PMCPMC11823614

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.