Evidence map›Paper›PMID 39745801›Full record

ArticleAmerican journal of epidemiology2025

Prospective pooled analyses of ambient ultraviolet radiation levels and risk of non-Hodgkin lymphoma and multiple myeloma.

Sophia S Wang, Kimberly A Bertrand, Emily L Deubler, Chun R Chao, Brenda M Birmann, Lauren R Teras, Bernard A Rosner, Marjorie McCullough, Yu-Hsiang Shu, Ke Wang and 5 more

Abstract read
In one paragraph

Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sophia S WangDivision of Health Analytics, Beckman Research Institute, City of Hope, Duarte, CA, United States.
Kimberly A BertrandSlone Epidemiology Center, Boston University, Boston, MA, United States.ORCID 0000-0002-4565-7618
Emily L DeublerDepartment of Population Science, American Cancer Society, Atlanta, GA, United States.ORCID 0000-0003-4511-1452
Chun R ChaoDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-7550-5498
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA, United States.
Bernard A RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-6907-0056
Marjorie McCulloughDepartment of Population Science, American Cancer Society, Atlanta, GA, United States.
Yu-Hsiang ShuDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States.
Ke WangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Charlie ZhongDepartment of Population Science, American Cancer Society, Atlanta, GA, United States.ORCID 0000-0001-6973-887X
Emily L CaubleDivision of Health Analytics, Beckman Research Institute, City of Hope, Duarte, CA, United States.
Alpa V PatelDepartment of Population Science, American Cancer Society, Atlanta, GA, United States.
James V LaceyDivision of Health Analytics, Beckman Research Institute, City of Hope, Duarte, CA, United States.
Myles CockburnNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Oil and Gas as Drivers of Climate Change and Health: Developing unique resources to investigate multi-level and diverse effects of exposure to oil and gas wellsU01CA199277 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V, MARTINEZ, MARIA ELENA · 2015 to 2024
$20.7M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
New Biospecimens to Enhance Research in the California Teachers Study CohortUM1CA164917 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V · 2012 to 2015
$10.1M
Risk factors for molecular subtypes of NHL a prospective evaluationR01CA202712 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BIRMANN, BRENDA M, WANG, SOPHIA S. · 2016 to 2020
$3.7M
A prospective analysis of peripheral blood cytokines and non-Hodgkin lymphomaR01CA149445 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BIRMANN, BRENDA M · 2011 to 2015
$3.0M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P01 CA087969NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA202712NCI NIH HHS R01 CA207020NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS U01 CA199277NCI NIH HHS UM1 CA164917NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NIH HHS P01 CA87969NIH HHS P30-CA023100NIH HHS P30-CA033572NIH HHS R01-CA077398NIH HHS R01 CA098122NIH HHS R01 CA149445NIH HHS R01CA202712NIH HHS R01- CA207020NIH HHS U01 CA167552NIH HHS U01 CA176726NIH HHS U01-CA199277NIH HHS UM1-CA164917NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Case-control studies of sun exposure and ultraviolet radiation (UVR) have consistently reported inverse associations with non-Hodgkin lymphoma (NHL) risk, but prospective studies have yielded mixed results. Few studies have explored these exposures in relation to multiple myeloma (MM) risk. To further evaluate these associations with NHL and MM risk and identify etiologically relevant exposure timing, we pooled data on 566 693 individuals from 6 US prospective cohort studies (11 636 incident NHL; 2749 incident MM; median follow-up: 20 years) and used geographic information systems models to estimate residential ambient UVR levels at time points from birth to adulthood. Using Cox proportional hazards models, we calculated hazard ratios (HRs) and 95% CIs for associations of residential ambient UVR levels with NHL overall, NHL subtypes, and MM, adjusted for study, age, and other putative risk factors. No UVR measures were significantly associated with NHL or NHL subtypes. Higher residential UVR levels during cohort follow-up were inversely associated with MM overall and among female patients (longitudinally updated HR per IQR increase: 0.74; 95% CI, 0.63-0.86) but not male patients (1.08; 95% CI, 0.90-1.29). Our results do not confirm an inverse association of adult ambient UVR levels with NHL risk. The MM findings require further investigation.

Indexed as

Environmental ExposureLymphoma, Non-HodgkinMultiple MyelomaUltraviolet RaysAdolescentAdultAgedChildFemaleHumansInfantMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk Factorscohorthematopoietic malignancieslongtitudinallymphomamyelomaNHLpooled analysessunultraviolet radiationUV

Identifiers

PMID39745801
PMCPMC12634110

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.