ArticleScience (New York, N.Y.)2025
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Optoelectronic Tweezers for Single-Cell Research: Principles, Applications, and Prospects.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- 2025: A year of resilience and resourcefulness.PLoS biology · 2025Article
- Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.Communications biology · 2025Article
- Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria.NPJ vaccines · 2025Article
- Emerging Molecular Mechanisms in Malaria Pathogenesis and Novel Therapeutic Approaches: A Focus onBiomolecules · 2025Review
- A 3D culture model facilitates mass production of in vitro Plasmodium falciparum haemolymph-like sporozoites.Malaria journal · 2025Article
- Targeting Bottlenecks in Malaria Transmission: Antibody-Epitope Descriptions Guide the Design of Next-Generation Biomedical Interventions.Immunological reviews · 2025Review
- Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.Science (New York, N.Y.) · 2025Article
- Induction of gametocytogenesis in human malaria parasites: from stress to genome editing.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors.
Cherrelle Dacon *Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-2347-2740
Re'em Moskovitz *Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-6091-1285
Kristian SwearingenInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0002-6756-4471
Lais Da Silva PereiraVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yevel Flores-GarciaDepartment of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-7230-3834
Maya AleshnickVaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-5471-4242
Sachie KanataniDepartment of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7072-0447
Barbara FlynnVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Alvaro Molina-CruzLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-5137-4836
Kurt WollenbergBioinformatics & Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4973-9370
Maria TraverLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-8267-4161
Payton KirtleyVaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, OR, USA.
Lauren PurserAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Marlon DillonVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8670-5487
Brian BonillaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4067-7476
Adriano FrancoAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Samantha PetrosAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Jake KritzbergAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-3962-0237
Courtney TuckerAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-8632-8952
Gonzalo Gonzalez PaezDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0003-4708-5753
Priya GuptaSeattle Children's Research Institute, Seattle, WA, USA.
Melanie J ShearsDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8226-4354
Joseph PazziAntigen Discovery, Incorporated, Irvine, CA, USA.
Joshua M EdgarAntigen Discovery, Incorporated, Irvine, CA, USA.ORCID 0009-0004-4905-3776
Andy A TengAntigen Discovery, Incorporated, Irvine, CA, USA.ORCID 0000-0002-2088-2181
Arnel BelmonteGeneral Dynamics Information Technology, Inc., Falls Church, VA, USA.ORCID 0000-0002-1738-6240
Kyosuke OdaAgile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA.ORCID 0009-0001-5186-6993
Safiatou DoumboMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.ORCID 0000-0002-0974-0860
Ludmila KrymskayaLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Jeff SkinnerMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-5697-0442
Shanping LiMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-0998-2082
Suman GhosalBioinformatics & Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kassoum KayentaoMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.ORCID 0000-0001-6877-0093
Aissata OngoibaMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.ORCID 0000-0002-8797-497X
Ashley VaughanSeattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0001-5815-756X
Joseph J CampoAntigen Discovery, Incorporated, Irvine, CA, USA.ORCID 0000-0002-8652-0917
Boubacar TraoreMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.
Carolina Barillas-MuryLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-4039-6199
Wathsala WijayalathAgile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA.
Azza IdrisVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1847-5488
Peter D CromptonMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-5629-0412
Photini SinnisDepartment of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-2954-7547
Brandon K WilderVaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-5577-7787
Fidel ZavalaDepartment of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-1414-6196
Robert A SederVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3133-0849
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-6469-2419
Joshua TanAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-6661-6372
Funding
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6MHuman monoclonal antibodies targeting infectious pathogensZIAAI001260 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TAN, JOSHUA · 2020 to 2025
$10.2MElucidating the role of TSR glycosylation in Plasmodium parasitesR01AI148489 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SWEARINGEN, KRISTIAN EDWARD · 2020 to 2024
$4.2MThe Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7MAcquisition of Fusion Lumos Orbitrap mass spectrometerS10OD026936 · OD · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2019 to 2019
$600kGates Foundation INV-004977Gates Foundation INV-005170Intramural NIH HHS ZIA AI001260NIAID NIH HHS R01 AI132359NIAID NIH HHS R01 AI148489NIGMS NIH HHS P30 GM133893NIH HHS S10 OD026936
Abstract
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the
Indexed as
Antibodies, MonoclonalAntibodies, ProtozoanEpitopesMalaria, FalciparumMalaria VaccinesPlasmodium falciparumProtozoan ProteinsSporozoitesAnimalsAntigens, ProtozoanHumansMiceAntibodies, MonoclonalAntibodies, ProtozoanAntigens, Protozoancircumsporozoite protein, ProtozoanEpitopesMalaria VaccinesProtozoan Proteins
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.