Evidence mapPaperPMID 39746739Full record

ArticleKidney international2025

Potential nuances in renoprotective properties of estrogen in females.

Lanette M Christensen, Matthew H Levine

Abstract read
In one paragraph

Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lanette M ChristensenDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Matthew H LevineDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Electronic address: matthew.levine@pennmedicine.upenn.edu.

Funding

Estrogen and Serms as Therapy for Renal Ischemia Reperfusion InjuryR01DK139679 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$704k
NIDDK NIH HHS R01 DK139679
6 · The paper itself

Abstract

A current study by Kitai et al. found that ovariectomy before estrogen/female sex hormone sensitization at puberty provided protection against kidney ischemia reperfusion injury, challenging the general consensus within the field that estrogen provides renoprotective function. These results are intriguing and could have important clinical implications, while requiring some clarification and substantiation of the conclusions reported.

Indexed as

EstrogensKidneyOvariectomyReperfusion InjuryAnimalsDisease Models, AnimalFemaleHumansSexual MaturationEstrogens

Identifiers

PMID39746739
PMCPMC12063498

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.