Evidence map›Paper›PMID 39746869›Full record

ArticlePhysiological reports2025

Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion.

Shelby Dahlen, Ipsita Mohanty, Bo Sun, Sanjana Nallapaneni, Patrick Osei-Owusu

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. G protein regulation by RGS proteins in the pathophysiology of dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shelby DahlenDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Ipsita MohantyDepartment of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Bo SunDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Sanjana NallapaneniDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Patrick Osei-OwusuDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4581-7044

Funding

In Vivo Mechanisms of Integrated G protein Signaling Regulation by RGS ProteinsR01HL139754 · NHLBI · DREXEL UNIVERSITY · PI OSEI-OWUSU, PATRICK · 2018 to 2021
$1.6M
Vascular Pyruvate Kinase M2 in HypertensionR01HL174004 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SATORU EGUCHI, Patrick Osei-Owusu · 2025 to 2026
$1.4M
Mechanisms of Impaired Renal Hemodynamics after Spinal Cord InjuryR56DK132859 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI OSEI-OWUSU, PATRICK · 2022 to 2022
$100k
Craig H. Neilsen Foundation (CHNF) 382566HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL139754HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL174004-01A1HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK132859NHLBI NIH HHS R01 HL139754NHLBI NIH HHS R01 HL174004NIDDK NIH HHS R56 DK132859
6 · The paper itself

Abstract

Sympathoexcitation is a hallmark of heart failure, with sustained β-adrenergic receptor (βAR)-G protein signaling activation. βAR signaling is modulated by regulator of G protein signaling (RGS) proteins. Previously, we reported that Gα

Indexed as

IsoproterenolMice, KnockoutRGS ProteinsVentricular RemodelingAdrenergic beta-AgonistsAnimalsMaleMiceMice, Inbred C57BLMyocytes, CardiacAdrenergic beta-AgonistsIsoproterenolRgs2 protein, mouseRgs5 protein, mouseRGS Proteinsadrenergic receptorscardiac physiologycardiomyopathyG protein signalingRGS

Identifiers

PMID39746869
PMCPMC11695115

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.