Evidence map›Paper›PMID 39747032›Full record

ArticleNature communications2025

Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila.

Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon, Li He

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in endocrinology · 2026
    Article
  5. Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Muhammad Ahmad *Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4909-5760
Shang Wu *The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Shengyao LuoYuanpei College, Peking University, Beijing, China.
Wenjia ShiDepartment of Applied Physics, Xi'an University of Technology, Xi'an, Shaanxi, China.
Xuan GuoLife Science Institute, Jinzhou Medical University, Jinzhou, Liaoning, China.ORCID 0000-0001-5259-7345
Yuansheng CaoDepartment of Physics, Tsinghua University, Beijing, China. yscao@tsinghua.edu.cn.ORCID 0000-0002-6857-6044
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.ORCID 0000-0001-7542-472X
Li HeThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. lihe19@ustc.edu.cn.ORCID 0000-0003-2155-606X

Funding

American Heart Association (American Heart Association, Inc.) 24PRE1189954National Natural Science Foundation of China (National Science Foundation of China) 32070750
6 · The paper itself

Abstract

Propagation of intercellular calcium waves through tissues has been found to coordinate different multicellular responses. Nevertheless, our understanding of how calcium waves operate remains limited. In this study, we explore the real-time dynamics of intercellular calcium waves in Drosophila adipose tissues. We identify Adipokinetic Hormone (AKH), the fly functional homolog of glucagon, as the key factor driving Ca

Indexed as

Adipose TissueAmino AcidsCalciumCalcium SignalingInsect HormonesOligopeptidesPyrrolidonecarboxylic AcidAnimalsBrainDrosophilaDrosophila melanogasterDrosophila ProteinsGlucagonHemolymphLarvaLipid Metabolismadipokinetic hormoneAmino AcidsCalciumDrosophila ProteinsGlucagonInsect HormonesOligopeptidesPyrrolidonecarboxylic Acid

Identifiers

PMID39747032
PMCPMC11696257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.