Evidence map›Paper›PMID 39747085›Full record

ArticleNature communications2025

Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation.

Yucheng Luo, Qiu Yin, Keke Chen, Zhaoyu Deng, Xiaozhou Liu, Yinning Zhou, Benpeng Zhu, Wenming Zhang, Zhichao Ma

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Spin-Orbit Angular Momentum Conversion in Coupled Nonparaxial Bessel Acoustic Vortices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yucheng LuoInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Qiu YinInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Keke ChenInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zhaoyu DengKey Laboratory of Modern Acoustics, Collaborative Innovation Center of Advanced Microstructures, Institute of Acoustics and School of Physics, Nanjing University, Nanjing, China.
Xiaozhou LiuKey Laboratory of Modern Acoustics, Collaborative Innovation Center of Advanced Microstructures, Institute of Acoustics and School of Physics, Nanjing University, Nanjing, China.
Yinning ZhouJoint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Macau, China.ORCID 0000-0003-2084-5804
Benpeng ZhuSchool of Integrated Circuit, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-5054-1495
Wenming ZhangState Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China. wenmingz@sjtu.edu.cn.ORCID 0000-0001-6743-1006
Zhichao MaInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. zhichaoma@sjtu.edu.cn.ORCID 0000-0003-1288-6745

Funding

National Natural Science Foundation of China (National Science Foundation of China) 12032015National Natural Science Foundation of China (National Science Foundation of China) 12121002National Natural Science Foundation of China (National Science Foundation of China) 12402062
6 · The paper itself

Abstract

Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels and the issue of missing embolization. Here, we propose an ultrasound-based method for embolic particle control in submillimeter vessels. The biocompatible ultrasound generated from an extrasomatic source can transmit through biological tissues, and exert forces on the intravital embolic particles. We show that the particles, influenced by these forces, are steerable to the target branch at vascular bifurcations. By modulating the ultrasound to adapt the vascular bifurcation distribution, the particles flowing in the micro-vessel networks are steered to the target branch and embolize it. The acoustic steering within ex vivo and in vivo models both verify the potential of this non-invasive particle control for precise and safe interventional therapy.

Indexed as

Embolization, TherapeuticAcousticsAnimalsHumansMice

Identifiers

PMID39747085
PMCPMC11696135

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.