ArticleScientific reports2025
U-shaped relationship between uric acid levels and all-cause mortality in patients with hypertension.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.Frontiers in nutrition · 2026Article
- Hyperuricemia was associated with metabolic response against brain injury instead of metabolism syndrome in Tibet: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts.Frontiers in nutrition · 2025Article
- Sex- and country-specific associations of hyperuricemia and inflammation with vascular aging across populations with diverse cardiovascular risks.Frontiers in medicine · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A correlation between UA levels and the development of hypertension has been demonstrated. However, the relationship between UA and all-cause mortality in patients with hypertension remains underexplored. A nonlinear association between UA and all-cause mortality across sexes was observed through smoothed curve fitting. The correlation between UA and all-cause mortality was calculated by threshold and saturation effect analysis, along with Cox regression models. The stability of the results in the presence of different comorbidities was verified through stratified analysis for interaction testing. Smoothed curve fitting was also used to examine the association between UA and various diseases. The association between UA and all-cause mortality in patients with hypertension exhibited a U-shaped curve, with inconsistent inflection points between the sexes. In male patients with hypertension, all-cause mortality gradually decreased with increasing UA levels when UA levels were ≤ 7.2 mg/dL (HR 0.975; 95% CI 0.929-1.024) and gradually increased with increasing UA levels when UA levels were > 7.2 mg/dL (HR 1.204; 95% CI 1.120-1.294). Similar findings were observed in female patients with hypertension, with UA as a protective factor when UA levels were ≤ 5.1 mg/dL (HR 0.902; 95% CI 0.820-0.991) and a risk factor when UA levels were > 5.1 mg/dL (HR 1.120; 95% CI 1.072-1.169). The association between UA and all-cause mortality in patients with hypertension exhibits a U-shaped curve. All-cause mortality tends to decrease and then increase with increasing UA levels, with the inflection point varying between sexes.
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