Evidence map›Paper›PMID 39747435›Full record

ArticleNature immunology2025

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans.

Mario Cortese, Thomas Hagan, Nadine Rouphael, Sheng-Yang Wu, Xia Xie, Dmitri Kazmin, Florian Wimmers, Shakti Gupta, Robbert van der Most, Margherita Coccia and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Trial
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  7. Decoding Immune Cell Doublets in Humans: From Artifacts to Insights.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Mario Cortese *Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.
Thomas Hagan *Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-5254-5251
Nadine RouphaelHope Clinic of the Emory Vaccine Center, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-2512-7919
Sheng-Yang WuInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.
Xia XieInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.
Dmitri KazminInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.
Florian WimmersInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6482-2228
Shakti GuptaDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Robbert van der MostGSK, Rixensart, Belgium.ORCID http://orcid.org/0000-0002-3065-6946
Margherita CocciaGSK, Rixensart, Belgium.ORCID http://orcid.org/0000-0003-1947-4735
Prabhu S AranuchalamInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0090-5689
Helder I NakayaHospital Israelita Albert Einstein, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5297-9108
Yating WangThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Elizabeth CoyleDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Shu HoriuchiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hanchih WuDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mary BowerHope Clinic of the Emory Vaccine Center, Decatur, GA, USA.
Aneesh MehtaHope Clinic of the Emory Vaccine Center, Decatur, GA, USA.
Clifford GunthelHope Clinic of the Emory Vaccine Center, Decatur, GA, USA.
Steve E BosingerEmory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2116-5061
Yuri KotliarovNIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6558-8883
Foo CheungNIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD, USA.
Pamela L SchwartzbergNIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6318-9187
Ronald N GermainNIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1495-9143
John TsangNIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3186-3047
Shuzhao LiThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Randy AlbrechtDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4008-503X
Hideki UenoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7747-0738
Shankar SubramaniamDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Mark J MulliganDivision of Infectious Diseases and Immunology, Department of Medicine and NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, NY, USA.
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-0593-7965
Hana GoldingDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Bali PulendranInstitute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.ORCID http://orcid.org/0000-0001-6517-4333

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITYR01AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2001 to 2024
$4.5M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NIAID NIH HHS R01 AI048638NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI167903NIH HHS P51 OD011132NIH HHS S10 OD026799
6 · The paper itself

Abstract

We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity. We found that TPO administration enhanced the durability of vaccine-induced antibody responses. TPO-activated megakaryocytes also promoted survival of human bone-marrow plasma cells through integrin β1/β2-mediated cell-cell interactions, along with survival factors APRIL and the MIF-CD74 axis. Using machine learning, we developed a classifier based on this platelet-associated signature, which predicted antibody response longevity across six vaccines from seven independent trials, highlighting a conserved mechanism for vaccine durability.

Indexed as

Antibodies, ViralAntibody FormationInfluenza VaccinesAdjuvants, ImmunologicAdultBlood PlateletsFemaleHumansInfluenza, HumanMaleMegakaryocytesPlasma CellsVaccinologyAdjuvants, ImmunologicAntibodies, ViralInfluenza Vaccines

Identifiers

PMID39747435
PMCPMC12158788

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.