Evidence map›Paper›PMID 39747549›Full record

ArticleScientific reports2025

Development of an advanced multimode refractive index plasmonic optical sensor utilizing split ring resonators for brain cancer cell detection.

Ali Khodaie, Hamid Heidarzadeh, Farrokhfar Valizadeh Harzand

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ali KhodaieDepartment of Electrical and Computer Engineering, University of Mohaghegh Ardabili, Ardabil, Iran.
Hamid HeidarzadehDepartment of Electrical and Computer Engineering, University of Mohaghegh Ardabili, Ardabil, Iran. heidarzadeh@uma.ac.ir.
Farrokhfar Valizadeh HarzandDepartment of Chemical Engineering, University of Mohaghegh Ardabili, Ardabil, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, we propose and theoretically investigate a novel multimode refractive index (MMRI) plasmonic optical sensor for detecting various brain cancer cells, leveraging the unique capabilities of split ring resonators (SRRs). The sensor, simulated using the finite-difference time-domain (FDTD) method, exhibits dual resonance modes in its reflection spectrum within the 1500 nm to 3500 nm wavelength range, marking a significant advancement in multimode plasmonic biosensing. Through detailed parametric analysis, we optimize critical dimensional parameters to achieve superior performance. The novelty of this work lies in the dual-mode sensing mechanism, which enables robust detection by exploiting the resonance characteristics of gold, silver, and aluminum. These materials provide tunable and highly sensitive interactions with light, enhancing the sensor's adaptability for a wide range of applications. The results reveal exceptional sensitivity values of 1778.3 nm/RIU, a limit of detection (LOD) of 0.016 RIU, and a high figure of merit (FOM) of 7 RIU

Indexed as

Biosensing TechniquesBrain NeoplasmsRefractometrySurface Plasmon ResonanceCell Line, TumorGoldHumansLimit of DetectionSilverGoldSilverBrain cancer cellsHigh sensitivityMultimode refractive index (MMRI)Optical sensorSplit ring resonator (SRR)

Identifiers

PMID39747549
PMCPMC11696276

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.