Trial reportNature medicine2025
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.
Trial report in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07440914 (Effects of Exercise-based Cardiac Rehabilitation in Patient With Congestive Heart Failure and Coexisting Knee Osteoarthritis), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Exercise-based Cardiac Rehabilitation in Patient With Congestive Heart Failure and Coexisting Knee Osteoarthritis
Who cites it
21 citing papers in PubMed.
- Bridging the post-hospitalization gap: a feasibility study of home-based rehabilitation in decompensated heart failure.ESC heart failure · 2026Trial
- Effects of Exercise Duration and Intensity on Maximal Exercise Capacity Over 6 Months in Coronary Heart Disease and Type 2 Diabetes-A Secondary Analysis of the LeIKDTrial.Scandinavian journal of medicine & science in sports · 2026Trial
- HEART Camp Connect-Promoting adherence to exercise in adults with heart failure with preserved ejection fraction.ESC heart failure · 2025Trial
- Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial.Nature medicine · 2025Trial
- Review
- Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.The Journal of physiology · 2026Article
- Heart failure and preserved ejection fraction: pathophysiology, clinical assessment, and management of exercise intolerance.European heart journal · 2026Review
- Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF): Epidemiology, Mechanisms, and the Role of Lifestyle Modification.Journal of cardiovascular development and disease · 2026Review
- A scalable, hyperstable intelligent fibre velocimeter for dynamic digitization of resistance training.National science review · 2026Article
- Article
- Combined strength and aerobic training vs. aerobic training alone in patients with heart failure: A systematic review and meta-analysis.Journal of sport and health science · 2026Review
- Sex Differences in the Impact of Physical Activity Across the Spectrum of Cardiovascular Disease.Current cardiology reports · 2026Review
- Heart Failure in the Molecular Era: Redefining Our Understanding of Disease Mechanisms and Perspectives.Biomedicines · 2026Review
- The Role of Brain Structure in Explaining Physical Functioning in Male Veterans With Impaired Kidney Function.Journal of the American Geriatrics Society · 2026Article
- Effects of exercises based on ACSM recommendations on patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2026Review
- Exercise in regional breast cancer with neoadjuvant anthracycline-based chemotherapy with immune checkpoint-inhibition: study protocol for a prospective randomised controlled trial.Frontiers in oncology · 2026Article
- Exercise Rehabilitation for Heart Failure and Associated Cardiomyopathies.Current cardiology reports · 2025Review
- Review
- Aerobic, resistance, and specialized exercise training in heart failure with preserved ejection fraction: A state-of-the-art review.Heart failure reviews · 2025Review
- Efficacy of different modes of exercise-based cardiac rehabilitation delivery for patients with heart failure: a systematic review and network meta-analysis.Cardiovascular diagnosis and therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
Endurance exercise training (ET) is an effective treatment in heart failure with preserved ejection fraction (HFpEF), but the efficacy of resistance training in this patient population has been only scarcely evaluated. In this multicenter, randomized trial, we evaluated the effects of combined endurance and resistance training over 12 months in patients with HFpEF. The primary endpoint was a modified Packer score, including all-cause mortality, hospitalizations classified as potentially related to heart failure or exercise and changes in peak oxygen consumption (
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.