ArticleBMC public health2025
Identifying joint association between body fat distribution with high blood pressure among 7 ∼ 17 years using the BKMR model: findings from a cross-sectional study in China.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible.Innovation (Cambridge (Mass.)) · 2026Article
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16 authors.
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Abstract
backgroundTo investigate the joint associations between various body fat distribution parameters and high blood pressure (HBP) using the Bayesian Kernel Machine Regression (BKMR) model in school-aged children.
methodsA diverse sample of 7 ∼ 17 years old (N = 1423; 50.25% boys) was recruited for this study. Fat distribution parameters for multiple body parts, including trunk, legs, android region, and gynoid region fat percentage were measured. HBP was defined as either systolic or diastolic blood pressure exceeded age-, sex- and height-specific 95th percentiles. The chi-square test was utilized to compare differences between groups. The BKMR model was employed to analyze the joint effects of body fat indicators on HBP while accounting for potential confounders. Weighted Quantile Sum (WQS) model was used to characterize the relative weights of each body fat distribution parameter for HBP. Additionally, stratified analyses were performed by sexes and overweight/non overweight groups.
resultsHBP prevalence was 46.86% and 35.10% for overweight and obese (OB) boys and girls, and was 17.96% and 17.28% for non-overweight and obese (non-OB) boys and girls, respectively. Increased fat percentages of trunk, android, and gynoid parts are associated with a higher risk of HBP, while increased fat percentage of the leg was associated with lower HBP risk. Android fat percentage contributed the most HBP risk in OB boys (weight = 0.34), OB girls (weight = 0.39), and non-OB girls (weight = 0.56). Leg fat percentage had significant protective effect on HBP for non-OB boys (weight=-0.22) and OB boys (weight=-0.44), while gynoid fat percentage had significant protective effect for OB girls (weight=-0.27).
conclusionsFat distribution of various body parts have inconsistent roles and directions in their association with HBP risk in children of different sex and weight status. We recommend that children of different sexes and weight statuses be provided with body-part-specific exercise recommendations for optimal chronic disease prevention and control benefits.
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