Evidence map›Paper›PMID 39748995›Full record

ReviewHeliyon2024

Antiviral and antibacterial peptides: Mechanisms of action.

Mahdyeh Neghabi Hajigha, Bahareh Hajikhani, Maryam Vaezjalali, Hossein Samadi Kafil, Raana Kazemzadeh Anari, Mehdi Goudarzi

Abstract readReview
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
  6. Article
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  13. Article
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  16. Review
  17. Article
  18. Article
  19. Article
  20. Anti-Antibiotics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahdyeh Neghabi HajighaStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahareh HajikhaniDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam VaezjalaliDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein Samadi KafilDrug Applied Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Raana Kazemzadeh AnariDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi GoudarziDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) present promising alternatives for addressing bacterial and viral multidrug resistance due to their distinctive properties. Understanding the mechanisms of these compounds is essential for achieving this objective. Therefore, this comprehensive review aims to highlight primary natural sources of AMPs and elucidate various aspects of the modes of action of antiviral and antibacterial peptides (ABPs). It emphasizes that antiviral peptides (AVPs) can disrupt the replication cycle of both enveloped and non-enveloped viruses at several stages, including pre-fusion, fusion, and post-entry into the host cell. Additionally, the review discusses the inhibitory effects of ABPs on bacterial growth, outlining their extracellular actions as well as their intracellular activities following membrane translocation. Factors such as structure, size, electric charge, environmental factors, degrading enzymes, and microbial resistance against AMPs can affect the function of AMPs.

Indexed as

Antibacterial peptideAntimicrobial peptideAntiviral peptideDrug resistanceMechanism of action

Identifiers

PMID39748995
PMCPMC11693924

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.