Evidence map›Paper›PMID 39749376›Full record

ArticleCancer science2025

Lymphocytes-Associated Extracellular Vesicles Activate Natural Killer Cells in HNSCC.

Chuwen Li, Chun Liu, Hailong Ma, Zhiyuan Zhang, Jianjun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chuwen LiDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Chun LiuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Hailong MaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-4110-1417
Zhiyuan ZhangDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Jianjun ZhangDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-8329-2357

Funding

CAMS Innovation Fund for Medical Sciences CIFMS 2019-I2M-5-037National Natural Science Foundation of China 81972573National Natural Science Foundation of China 82173148National Natural Science Foundation of China 82272983Original Exploration Project of Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine JYYC010Shanghai Clinical Research Center for Oral Diseases 19MC1910600Shanghai Municipal Key Clinical Specialty shslczdzk01601Shanghai's Top Priority Research Center 2022ZZ01017The Innovative Research Team of High-level Local Universities in Shanghai SHSMU-ZLCX20212300The Innovative Research Team of High-level Local Universities in Shanghai SHSMU-ZLCX20212301
6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) facilitate intercellular communication and play a pivotal role in tumor progression. Accumulated evidence has indicated the diversity of sEVs but with limited results revealing the landscape of heterogeneity of sEVs. The heterogeneity of cargo RNA in sEVs presents the different cell origins and indicates different functions. Here, we analyzed the heterogeneity of sEVs at droplet levels from single-cell RNA sequencing results of head and neck squamous cell carcinoma (HNSCC) with the previously reported algorithm SEVtras. With the sEVs secretion activity calculated by SEVtras, we also found that the T cells held the major role of sEVs secretion. In addition, we found these sEVs secreted by T cells increased the cytotoxic ability of natural killer cells (NK cells), which illustrated an indirect manner for the anti-tumor function of T cells. These results revealed the heterogeneity of cargo RNA of sEVs in HNSCC and underlined a sEVs-dependent manner in which T cells act on NK cells and anti-tumor immunity.

Indexed as

Extracellular VesiclesHead and Neck NeoplasmsKiller Cells, NaturalSquamous Cell Carcinoma of Head and NeckT-LymphocytesCell CommunicationCell Line, TumorHumansLymphocyte ActivationSingle-Cell Analysishead and neck squamous cell carcinomanatural killer cellssingle‐cell RNA‐sequencingsmall extracellular vesiclesT cells

Identifiers

PMID39749376
PMCPMC11875761

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.