Evidence map›Paper›PMID 39749895›Full record

ArticleJournal of clinical laboratory analysis2025

Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.

Elmutuz H Elssaig, Eltayib H Ahmed-Abakur, Tarig M S Alnour, Mohammed A Alsubai, Abdalla Eltoum Ali, Mohammad Fahad Ullah, Nizar H Saeedi, Fahad Daefalah Alenzi

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Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Impact ofInternational journal of medical sciences · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elmutuz H ElssaigDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.ORCID https://orcid.org/0000-0003-3136-1899
Eltayib H Ahmed-AbakurDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Tarig M S AlnourDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.ORCID https://orcid.org/0000-0001-5880-793X
Mohammed A AlsubaiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Abdalla Eltoum AliFaculty of Medical Laboratory Science, Department of Clinical Chemistry Alzaiem Alazhari University, Khartoum North, Sudan.ORCID https://orcid.org/0000-0001-9005-0375
Mohammad Fahad UllahDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Nizar H SaeediDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.ORCID https://orcid.org/0000-0002-9281-1550
Fahad Daefalah AlenziMedical Laboratory Specialist- Clinical Chemistry Lab -King Fahd Specialist Hospital, Tabuk, Kingdom of Saudi Arabia, Saudi Arabia.

Funding

Deanship of Scientific Research (DSR), University of Tabuk, Kingdom of Saudi Arabia S-0115-1439
6 · The paper itself

Abstract

objectivesTo determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.

methodsThis study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).

resultsThe results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively. High frequencies of haplotypes TA and TC were observed in type 2 diabetes patients.

conclusionThe present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.

Indexed as

Diabetes Mellitus, Type 2Genetic Predisposition to DiseasePolymorphism, Single NucleotideRNA-Binding ProteinsAdultAgedCase-Control StudiesFemaleGene FrequencyHaplotypesHumansInsulin-Like PeptidesMaleMiddle AgedSaudi ArabiaIGF2BP2 protein, humanInsulin-Like PeptidesRNA-Binding ProteinsBMIgenetic variantsgenomic markersIGF2BP2SNPsT2DM

Identifiers

PMID39749895
PMCPMC11821720

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.