Trial reportEuropean journal of nutrition2025
The effects of dietary protein on physical performance and body composition in middle age and older people having type II diabetes mellitus: a randomized pilot study.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.Aging clinical and experimental research · 2025Pooled it
- Effects of Higher Dietary Protein Intake on Isokinetic Muscle Performance in Older Adults with Type 2 Diabetes Mellitus.Journal of functional morphology and kinesiology · 2026Article
- The impact of a complete nutrition diabetic formula on glycemic control and nutritional status in hospitalized patients with diabetes mellitus.Frontiers in endocrinology · 2025Article
- Constructing the prediction model based on DXA between sarcopenia and BMD in middle-aged and elderly men with T2DM.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProtein supplementation has been proposed as an effective dietary strategy for maintaining or increasing skeletal muscle mass and improving physical performance in middle-aged and older adults. Diabetes mellitus exacerbates muscle mass loss, leading to many older adults with type 2 diabetes mellitus (T2DM) experiencing sarcopenia, and vice versa. Our objective was to assess the impact of increased dietary protein intake on muscle mass, strength, physical performance, and the progression of T2DM in middle-aged and older adults diagnosed with this condition.
methodsA 12-week randomized, controlled, parallel pilot study was conducted with 26 patients diagnosed with T2DM and had either low muscle mass, or low muscle strength or poor physical performance (age > 55 years old), aiming to investigate the effects of a protein-rich diet in sarcopenic and metabolic markers. The control group received 0.8-1.0 g/kg/day, while the intervention group received 1.2-1.5 g/kg/day of protein respectively. Body composition, muscle mass/strength and biochemical parameters were measured before and after the intervention period.
resultsDifferent kinetics of skeletal muscle index (SMI), appendicular lean mass (ALM), hand grip strength (HGS), gait speed (GS) and standing balance (SB) (p < 0.05) were observed between two groups. Specifically, the intervention group showed a significant improvement in HGS (p < 0.001) and physical performance (timed-up-and-go, p < 0.001; GS, p = 0.011; SB, p = 0.022), while the control group had its ALM (p = 0.014), SMI (p = 0.011) and HGS (p = 0.011) significantly reduced. The kinetics of metabolic markers indices was similar for both groups.
conclusionCurrent recommendation for protein intake (0.8-1 g/kg/day) is certainly not enough to ameliorate the muscle mass loss in middle age and older adults' individuals with T2DM. In contrast, protein intake of 1.2-1.5 g/kg/day seems to be a more appropriate recommendation to combat upcoming sarcopenia, nonetheless the progression of T2DM was not interrupted.
Indexed as
Identifiers
39751920What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.