ArticleDiabetes care2025
Incidence and Risk Factors of Diagnosed Young-Adult-Onset Type 2 Diabetes in the U.S.: The National Health Interview Survey 2016-2022.
Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dementia in type 2 diabetes: risk factors, disease processes and opportunities for prevention across the lifespan.Diabetologia · 2026Review
- Clinical characteristics, disease course, and clinical subgroups of young adults with type 2 diabetes.Journal of the Endocrine Society · 2026Article
- Sex-stratified associations of TyG index and HOMA-IR changes with incident type 2 diabetes.Scientific reports · 2026Article
- Article
- China precision nutrition biobank: protocol of a prospective cohort study on diet, human phenotype/genotype, and early-onset chronic diseases.Nutrition journal · 2025Article
- Prevalence, Demographic and Clinical Characteristics of Individuals with Early Onset Type 2 Diabetes in the USA: an NHANES Analysis 1999-2020.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Management of Early-Onset Type 2 Diabetes in Adults: Current Evidence and Future Directions.Diabetes & metabolism journal · 2025Review
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- Confluence of Diabetes Risk.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between the triglyceride-glucose index and hyperuricemia in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Young patients with type 2 diabetes have high relative risks for complications in a country with middle-high sociodemographic index, similarly to those countries with high index.Frontiers in endocrinology · 2025Review
- Risk factors for advance stage cardiovascular-renal-metabolic syndrome in patients with early-onset type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveTo estimate the incidence and identify risk factors for diagnosed type 2 diabetes (T2D) among young U.S. adults. RESEARCH DESIGN AND
methodsWe analyzed 142,884 adults aged 18-79 years with self-reported diabetes type from the cross-sectional National Health Interview Survey in 2016-2022, representing the noninstitutionalized U.S. civilian population. Incidence of diagnosed T2D was calculated for three age groups: young-adult onset (18-44 years), middle-age onset (45-64 years), and older-adult onset (65-79 years); the latter two groups were included to highlight the distinct risk factor profile of young-adult-onset T2D. Multivariable logistic regressions were used to identify risk factors for young-adult-onset T2D.
resultsThe estimated incidence of diagnosed young-adult-onset T2D was 3.0 per 1,000 adults (95% CI 2.6-3.5). Minority groups, socioeconomically disadvantaged individuals, and people with cardiometabolic diseases or psychological conditions had a higher incidence of diagnosed young-adult-onset T2D compared with their counterparts. Lipid-lowering medication use (adjusted odds ratio [aOR] 13.15, 95% CI 8.85-19.55), antihypertensive medication use (aOR 11.89, 95% CI 7.97-17.73), and obesity (BMI ≥30 vs. <25 kg/m2, aOR 10.89, 95% CI 6.69-17.7) were the strongest risk factors for young-adult-onset T2D; these risk factors, along with hypertension, hyperlipidemia, and coronary heart disease, were more strongly associated with young-adult-onset T2D compared with later-onset T2D, with up to 4.5 times higher aORs.
conclusionsThis study quantified the incidence of diagnosed young-adult-onset T2D in U.S. adults and identified its distinct risk factor profile. Targeted prevention strategies for young-adult-onset T2D are needed for minority and socioeconomically disadvantaged people and those with cardiometabolic diseases.
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