Evidence map›Paper›PMID 39752867›Full record

ArticleJournal of food and drug analysis2024

Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects.

Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food and drug analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Comparative Efficacy ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chen-Che HsiehInstitute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan, R.O.C.
Chih-Yao HouDepartment of Seafood Science, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan, R.O.C.
Hsiao-Yun LeiInstitute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan, R.O.C.
Darin KhumsupanInstitute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan, R.O.C.
Huey-Jine ChaiSeafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan, R.O.C.
Pek-Kui LimSchool of Food Studies and Gastronomy, Taylor's University, Subang Jaya, Selangor 47500, Malaysia.
Cheng-Chih HsuDepartment of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan, R.O.C.
Sz-Jie WuDepartment of Horticulture and Landscape Architecture, National Taiwan University, Taipei, Taiwan, R.O.C.
Kai-Wen ChengDepartment of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan, R.O.C.
Yi-Chen ChenDepartment of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan, R.O.C.
Kuan-Chen ChengInstitute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.

Indexed as

GanodermaMelaninsMolecular Docking SimulationMonophenol MonooxygenaseZebrafishAnimalsCell Line, TumorEnzyme InhibitorsHumansMelanomaPlant ExtractsEnzyme InhibitorsMelaninsMonophenol MonooxygenasePlant Extracts

Identifiers

PMID39752867
PMCPMC11698587

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.