ArticleJournal of psychiatry & neuroscience : JPN
Correlation between polygenic risk scores of depression and cortical morphology networks.
Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Peripheral immune-redox signatures associate with cortical network alterations in anhedonic depression.Molecular psychiatry · 2026Article
- Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.BMC psychiatry · 2026Article
- Molecular Mechanisms Explaining Neuroanatomical Subtypes in Major Depressive Disorder: Insights From Cortical Morphometric Inverse Divergence.Human brain mapping · 2025Article
- Investigation of cerebral cortical morphological similarity and network topological abnormalities in hepatic encephalopathy utilizing a morphometric inverse divergence network framework.Frontiers in neurologyArticle
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Authors and funding
11 authors.
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Abstract
backgroundCortical morphometry is an intermediate phenotype that is closely related to the genetics and onset of major depressive disorder (MDD), and cortical morphometric networks are considered more relevant to disease mechanisms than brain regions. We sought to investigate changes in cortical morphometric networks in MDD and their relationship with genetic risk in healthy controls.
methodsWe recruited healthy controls and patients with MDD of Han Chinese descent. Participants underwent DNA extraction and magnetic resonance imaging, including
resultsWe included 130 healthy controls and 195 patients with MDD. The results indicated enhanced connectivity in the MIND network among patients with MDD and people with high genetic risk, particularly in the somatomotor (SMN) and default mode networks (DMN). We did not observe significant findings in the MSN. The white matter network showed disruption among people with high genetic risk, also primarily in the SMN and DMN. The MIND network outperformed the MSN network in distinguishing MDD status. LIMITATIONS: Our study was cross-sectional and could not explore the causal relationships between cortical morphological changes, white matter connectivity, and disease states. Some patients had received antidepressant treatment, which may have influenced brain morphology and white matter network structure.
conclusionThe genetic mechanisms of depression may be related to white matter disintegration, which could also be associated with decoupling of the SMN and DMN. These findings provide new insights into the genetic mechanisms and potential biomarkers of MDD.
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