Evidence map›Paper›PMID 39753357›Full record

ArticleeNeuro2025

TrkB Agonist (7,8-DHF)-Induced Responses in Dorsal Root Ganglia Neurons Are Decreased after Spinal Cord Injury: Implication for Peripheral Pain Mechanisms.

Kyeongran Jang, Sandra M Garraway

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kyeongran JangDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, Georgia 30322.
Sandra M GarrawayDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, Georgia 30322 smgarraway@emory.edu.ORCID https://orcid.org/0000-0002-3297-1456

Funding

Examining the roles A-delta LTMRs and BDNF signaling play in neuropathic pain after SCIR01NS102850 · NINDS · EMORY UNIVERSITY · PI GARRAWAY, SANDRA M. · 2018 to 2022
$1.9M
Peripheral BDNF drives primary afferent hyperexcitability and pain hypersensitivityR21NS116665 · NINDS · EMORY UNIVERSITY · PI GARRAWAY, SANDRA M. · 2020 to 2020
$425k
NINDS NIH HHS R01 NS102850NINDS NIH HHS R21 NS116665
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) are known to contribute to both protective and pronociceptive processes. However, their contribution to neuropathic pain after spinal cord injury (SCI) needs further investigation. In a recent study utilizing TrkB

Indexed as

FlavonesGanglia, SpinalNeuralgiaNeuronsReceptor, trkBSpinal Cord InjuriesAnimalsDisease Models, AnimalHyperalgesiaMaleMiceMice, Inbred C57BL6,7-dihydroxyflavoneFlavonesNtrk2 protein, mouseReceptor, trkBDRGpainperipheralsensory neuronspinal cord injuryTrkB signaling

Identifiers

PMID39753357
PMCPMC11728855

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.