Evidence map›Paper›PMID 39753731›Full record

ArticleNature nanotechnology2025

Autophagosomes coated in situ with nanodots act as personalized cancer vaccines.

Wei-Qiang Huang, Wei You, Ya-Qi Zhu, Fan Gao, Zhi-Zhi Wu, Guang Chen, Jun Xiao, Qi Shao, Long-Hai Wang, Xuan Nie and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei-Qiang HuangDepartment of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-2660-1117
Wei YouHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Ya-Qi ZhuDepartment of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-9754-3217
Fan GaoHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-5133-4102
Zhi-Zhi WuDepartment of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
Guang ChenHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. gchen@ustc.edu.cn.ORCID http://orcid.org/0000-0002-2965-2614
Jun XiaoDepartment of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. ixiaojun@ustc.edu.cn.ORCID http://orcid.org/0000-0001-9012-1110
Qi ShaoHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Long-Hai WangHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. hiwang@ustc.edu.cn.ORCID http://orcid.org/0000-0002-6529-7031
Xuan NieHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7757-9538
Ze ZhangHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Chun-Yan HongHefei National Research Centre for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. hongcy@ustc.edu.cn.ORCID http://orcid.org/0000-0002-5295-4741
Ye-Zi YouDepartment of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. yzyou@ustc.edu.cn.ORCID http://orcid.org/0000-0003-0319-4165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagosome cancer vaccines can promote cross-presentation of multiple tumour antigens and induce cross-reactive T cell responses. However, so far, there is no effective method for obtaining a highly immunogenic autophagosomal cancer vaccine because autophagosomes, once formed, quickly fuse with lysosomes and cannot easily escape from cells. Here we report a functional Ti

Indexed as

AutophagosomesCancer VaccinesNanoparticlesNeoplasmsAnimalsCell Line, TumorFemaleHumansLysosomesMicePrecision MedicineCancer Vaccines

Identifiers

PMID39753731

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.