Evidence map›Paper›PMID 39754658›Full record

ReviewCurrent hematologic malignancy reports2025

Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies.

Praneeth Reddy Keesari, Diana Samuels, Charan Thej Reddy Vegivinti, Yashwitha Sai Pulakurthi, Revathi Kudithi, Meekoo Dhar, Murali Janakiram

Abstract readReview
In one paragraph

Review in Current hematologic malignancy reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Clinical Benefit and Global Regulation of Bispecific Antibody Drugs: A Cross-sectional Analysis.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Bispecific Antibodies in Hematologic Malignancies: Attacking the Frontline.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Praneeth Reddy KeesariDepartment of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Diana SamuelsDepartment of Pharmacy, City of Hope National Medical Center, Duarte, CA, USA.
Charan Thej Reddy VegivintiDepartment of Hematology-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yashwitha Sai PulakurthiDepartment of Internal Medicine, New York Medical College - Saint Michael's Medical Center, Newark, NJ, USA.
Revathi KudithiDepartment of Internal Medicine, Kakatiya Medical College, Warangal, Telangana, India.
Meekoo DharDepartment of Hematology-Oncology, Staten Island University Hospital, Staten Island, NY, USA.
Murali JanakiramDivision of Myeloma, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA. mjanakiram@coh.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewMultiple myeloma is a chronic malignancy and with evolving treatment options, understanding the economic burden and cost-effectiveness of therapies is crucial for clinicians and researchers. RECENT

findingsIn this, we review the recent approval of Bispecific antibodies and CAR-T for myeloma and their cost implications, including direct and indirect costs. We compare this to current regimens and provide cost comparisons in this review. We conclude that the use of more effective therapies such as CAR-T in earlier lines of therapies may be more cost-effective depending on the country and model used. Further studies are essential to better understand the cost-effectiveness of bispecific antibodies including head-to-head comparisons to CAR-T therapy.

Indexed as

Antibodies, BispecificCost-Benefit AnalysisImmunotherapy, AdoptiveMultiple MyelomaCost of IllnessHumansAntibodies, BispecificBispecific antibodiesCAR-TCost-effectivenessEconomicMultiple Myeloma

Identifiers

PMID39754658
PMCPMC11700040

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.