Evidence map›Paper›PMID 39754724›Full record

GuidelineUnited European gastroenterology journal2025

European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.

Carolina Malagelada, Jutta Keller, Daniel Sifrim, Jordi Serra, Jan Tack, Agata Mulak, Andreas Stengel, Ariadna Aguilar, Asbjorn Mohr Drewes, Axel Josefsson and 25 more

Abstract readPractice Guideline
In one paragraph

Guideline in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gutflix 'How to Develop Guidelines' Series.United European gastroenterology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Carolina MalageladaDigestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.ORCID 0000-0001-7097-1492
Jutta KellerIsraelitic Hospital, Academic Hospital University of Hamburg, Hamburg, Germany.ORCID 0000-0002-5884-1115
Daniel SifrimWingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4894-0523
Jordi SerraDigestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.ORCID 0000-0003-2120-6270
Jan TackDepartment of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium.ORCID 0000-0002-3206-6704
Agata MulakDepartment of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland.ORCID 0000-0003-4678-8393
Andreas StengelClinic for Psychosomatic Medicine and Psychotherapy Klinikum Stuttgart, Psychosomatic Medicine and Psychotherapy University Hospital Tübingen, DZPG Site Tübingen, Charité-Universitätsmedizin Freie Universität Berlin, Berlin, Germany.
Ariadna AguilarDigestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Asbjorn Mohr DrewesMech-Sense & Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Axel JosefssonDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bruno BonazStress et Interactions Neuro-Digestives, Grenoble Institut des Neurosciences, Centre de Recherche INSERM 836 UJF-CEA-CHU, Grenoble, France.
Dan DumitrascuSecond Department of Internal Medicine and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Daniel KeszthelyiDepartment of Gastroenterology-Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID 0000-0001-9856-9980
Elizabeth BarbaNeurogastroenterology and Motility Unit, Gastroenterology Department, Institut Clínic de Malalties Digestives i Metabòliques Hospital Clinic of Barcelona, Barcelona, Spain.ORCID 0000-0002-5986-6592
Florencia CarboneDepartment of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Frank ZerbibCHU de Bordeaux, Centre Médico-chirurgical Magellan, Hôpital Haut-Levêque, Department of Gastroenterology, Université de Bordeaux, INSERM CIC 1401, Bordeaux, France.ORCID 0000-0002-6802-2121
Giovanni MarchegianiDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Padua, Italy.
Goran HauserDepartment of Gastroenterology, Clinical Hospital Centre of Rijeka, Faculty of Medicine University of Rijeka, Rijeka, Croatia.
Guillaume GourcerolPhysiology Department, Univ Rouen Normandie, Inserm, ADEN UMR 1073, CHU Rouen, Rouen, France.
Hans TornblomDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-2117-9874
Heinz HammerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.ORCID 0000-0001-8683-4951
Imran AzizDepartment of Gastroenterology and Division of Clinical Medicine, University of Sheffield, Sheffield, UK.ORCID 0000-0003-4313-0553
Jelena Rakic MaticHealth Center Zagreb-West, Zagreb, Croatia.
Juan MendiveLa Mina Primary Care Academic Health Centre, Catalan Institute of Health, University of Barcelona, Barcelona, Spain.
Kornilia NikakiDepartment of Pediatric Gastroenterology, Great Ormond Street Hospital, London, UK.
Lucas WautersDepartment of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-3195-4996
Luis Gerardo Alcalá-GonzálezDigestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0003-3247-1539
Marek WalugaDepartment of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
Mariana JingaDepartment of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Maura CorsettiNIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
Nathalie RommelDepartment of Neurosciences, Deglutology, Experimental Otorhinolaryngology (ExpORL), University of Leuven, Leuven, Belgium.
Ray ShidrawiDepartment of Gastroenterology, The Wellington Hospital, London, UK.
Roberto De GiorgioDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Sritharan KadirkamanathanDepartment of Gastroenterology, Wingate Institute of Neurogastroenterology, The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Teodora Surdea-BlagaSecond Department of Internal Medicine and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Funding

United European Gastroenterology
6 · The paper itself

Abstract

introductionChronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut-brain interaction disorders should be assessed. United European Gastroenterology (UEG) and the European Society for Neurogastroenterology and Motility (ESNM) identified the need for an updated, evidence-based clinical guideline for the management of chronic nausea and vomiting.

methodsA multidisciplinary team of experts in the field, including European specialists and national societies, participated in the development of the guideline. Relevant questions were addressed through a literature review and statements were developed and voted on according to a Delphi process.

resultsNinety-eight statements were identified and voted following the Delphi process. Overall agreement was high, although the grade of scientific evidence was low in many areas. Disagreement was more evident for some pharmacological treatment options. A diagnostic algorithm was developed, focussing on the differentiating features between gastrointestinal motility and gut-brain interaction disorders with predominant nausea and vomiting.

conclusionThese guidelines provide an evidence-based framework for the evaluation and treatment of patients with chronic nausea and vomiting.

Indexed as

AntiemeticsGastroenterologyNauseaVomitingAlgorithmsChronic DiseaseConsensusDelphi TechniqueEuropeEvidence-Based MedicineGastrointestinal MotilityHumansSocieties, MedicalAntiemeticsDelphiguidelinesnauseavomiting

Identifiers

PMID39754724
PMCPMC11999049

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.