Evidence map›Paper›PMID 39755028›Full record

ArticleCell calcium2025

Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon.

Salah A Baker, Manushri Karwa, Ji Yeon Lee, Sarah Riar, Bernard T Drumm, Kenton M Sanders

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salah A BakerDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA. Electronic address: sabubaker@med.unr.edu.
Manushri KarwaDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA.
Ji Yeon LeeDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA.
Sarah RiarDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA.
Bernard T DrummSmooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, A91K584, Ireland.
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, 89557, USA. Electronic address: ksanders@med.unr.edu.

Funding

Role of interstitial cells of Cajal in patterned colonic motor activityR01DK120759 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Sal Baker, KENTON M SANDERS · 2019 to 2026
$3.4M
NIDDK NIH HHS R01 DK120759
6 · The paper itself

Abstract

Interstitial cells of Cajal in the plane of the myenteric plexus (ICC-MY) serve as electrical pacemakers in the stomach and small intestine. A similar population of cells is found in the colon, but these cells do not appear to generate regular slow wave potentials, as characteristic in more proximal gut regions. Ca

Indexed as

Biological ClocksCalcium SignalingColonInterstitial Cells of CajalMyenteric PlexusAnimalsAnoctamin-1CaffeineCalciumChloride ChannelsIndolesMiceANO1 protein, mouseAnoctamin-1CaffeineCalciumChloride Channelscyclopiazonic acidIndolesCa(2+) imagingColonic motilityPacemakerPeristalsisVoltage-dependent Ca(2+) current

Identifiers

PMID39755028
PMCPMC11737426

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.